INT221379

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 4.08
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ltb4r1) plasma membrane (Ltb4r1) signal transducer activity (Ltb4r1)
Anatomy Link Frequency
epithelium 2
Ltb4r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 91 97.04 Very High Very High Very High
Inflammatory response 19 94.12 High High
COX2 1 50.00 Quite Low
agonist 17 47.60 Quite Low
Inflammatory mediators 14 40.32 Quite Low
cytokine 9 36.16 Quite Low
rheumatoid arthritis 1 30.32 Quite Low
cINOD 8 29.04 Quite Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 214 98.88 Very High Very High Very High
INFLAMMATION 129 97.04 Very High Very High Very High
Infection 2 88.92 High High
Nicotine Addiction 40 82.72 Quite High
Cancer 68 50.00 Quite Low
Disease 11 31.28 Quite Low
Rheumatoid Arthritis 1 30.32 Quite Low
Inflammatory Bowel Disease 1 28.32 Quite Low
Necrosis 1 6.24 Low Low
Hypoxia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ability of LTB4 to activate PPAR?
Positive_regulation (activate) of Localization (ability) of LTB4
1) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2490577 Disease Relevance 1.01 Pain Relevance 0.47
Also, LPS-induced release of IL-8 and PGE2 from COPD and non-COPD BES increased progressively overtime and peaked by 24 h, whereas LTB4 release increased up to 4 h and remained constant thereafter (Fig. 4D,E,F).
Positive_regulation (increased) of Localization (release) of LTB4 associated with pulmonary disease
2) Confidence 0.03 Published 2007 Journal Respir Res Section Body Doc Link PMC2214730 Disease Relevance 1.69 Pain Relevance 0.03
To our knowledge no previous studies have analyzed basal or LPS-induced PGE2 and LTB4 release by bronchial epithelium in COPD.
Positive_regulation (induced) of Localization (release) of LTB4 in epithelium associated with pulmonary disease
3) Confidence 0.03 Published 2007 Journal Respir Res Section Body Doc Link PMC2214730 Disease Relevance 1.38 Pain Relevance 0.14

General Comments

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