INT221386

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.53
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4, IL8) intracellular (Tlr4, IL8) extracellular space (IL8)
extracellular region (IL8) plasma membrane (Tlr4) cytoplasm (Tlr4)
Anatomy Link Frequency
T lymphocytes 4
THP-1 2
epithelial cell 2
Tlr4 (Mus musculus)
IL8 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 60 100.00 Very High Very High Very High
antagonist 24 98.40 Very High Very High Very High
Inflammation 163 95.36 Very High Very High Very High
agonist 14 91.16 High High
Inflammatory mediators 10 88.96 High High
chemokine 29 87.36 High High
Inflammatory response 30 73.52 Quite High
Inflammatory stimuli 7 54.92 Quite High
metalloproteinase 19 5.00 Very Low Very Low Very Low
ketamine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 251 99.44 Very High Very High Very High
Nicotine Addiction 69 98.08 Very High Very High Very High
INFLAMMATION 206 95.36 Very High Very High Very High
Fungal Infection 3 90.40 High High
Critical Illness 2 84.00 Quite High
Sepsis 41 81.68 Quite High
Bacterial Infection 3 66.56 Quite High
Sprains And Strains 9 63.56 Quite High
Hypoxia 2 57.04 Quite High
Injury 12 54.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonetheless, vitamin D3 pretreatment resulted in decreased LPS-induced IL-6 and IL-8 production and blocked NF?
LPS Positive_regulation (induced) of Gene_expression (production) of IL-8
1) Confidence 0.14 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2855078 Disease Relevance 0.35 Pain Relevance 0.04
B and IKK-2 impaired the CXCL8 expression this points to a TLR4 and NF-?
TLR4 Positive_regulation (points) of Gene_expression (expression) of CXCL8
2) Confidence 0.07 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 0.44 Pain Relevance 0.26
As expected, it should be pointed that LPS-induced IL-8 levels varied among COPD patients, suggesting that epithelial cell responsiveness to LPS cannot alone explain the complex inflammatory process of COPD.
LPS Positive_regulation (induced) of Gene_expression (levels) of IL-8 in epithelial cell associated with pulmonary disease and inflammation
3) Confidence 0.05 Published 2007 Journal Respir Res Section Body Doc Link PMC2214730 Disease Relevance 1.79 Pain Relevance 0.20
Indeed, it was found that a constitutively active mutant of human TLR4, transfected into a monocytic cell line, could induce the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and IL-8 as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve T lymphocytes [66].
TLR4 Positive_regulation (induce) of Gene_expression (expression) of IL-8 in T lymphocytes associated with cytokine
4) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.27 Pain Relevance 0.11
Indeed, it was found that a constitutively active mutant of human TLR4, transfected into a monocytic cell line, could induce the activation of NF-kappaB and the expression of the proinflammatory cytokines IL-1, IL-6, and IL-8 as well as the expression of the costimulatory molecule CD80 (B7.1), which is required for the activation of naïve T lymphocytes [66].
TLR4 Positive_regulation (induce) of Gene_expression (expression) of IL-8 in T lymphocytes associated with cytokine
5) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2817369 Disease Relevance 0.32 Pain Relevance 0.11
Conversely, the P2RY6 receptor antagonists, anthraquinone-sulfonic acid derivative reactive blue 2 and suramin, inhibited LPS-induced IL-8 production by THP-1 cells [24].
LPS Positive_regulation (induced) of Gene_expression (production) of IL-8 in THP-1 associated with antagonist
6) Confidence 0.00 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.35 Pain Relevance 0.19

General Comments

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