INT221409

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2007
Last Reported 2011
Negated 2
Speculated 1
Reported most in Body
Documents 8
Total Number 14
Disease Relevance 5.53
Pain Relevance 2.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Anatomy Link Frequency
neuronal 2
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
electroacupuncture 574 99.24 Very High Very High Very High
agonist 12 97.80 Very High Very High Very High
Hippocampus 6 97.24 Very High Very High Very High
Inflammation 20 95.36 Very High Very High Very High
Acupuncture 70 95.04 Very High Very High Very High
withdrawal 4 78.64 Quite High
tolerance 49 75.88 Quite High
cOX1 7 74.28 Quite High
Pain 16 5.00 Very Low Very Low Very Low
Neuropeptide 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 21 99.90 Very High Very High Very High
Death 90 99.04 Very High Very High Very High
Neuroblastoma 41 98.36 Very High Very High Very High
Aging 13 97.92 Very High Very High Very High
Neurodegenerative Disease 27 96.40 Very High Very High Very High
INFLAMMATION 21 95.36 Very High Very High Very High
Insulin Resistance 182 94.64 High High
Apoptosis 139 94.64 High High
Cancer 28 93.12 High High
Repression 13 88.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that SIRT1 may be regulated posttranscriptionally.
Spec (may) Regulation (regulated) of SIRT1
1) Confidence 0.58 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.07 Pain Relevance 0.41
In the fruit fly and the nematode, the effect that resveratrol had on lifespan was dependent on Sir2 and SIR-2.1, the respective homologues of the mammalian protein, SIRT-1.
Regulation (dependent) of Sir2 associated with lifespan
2) Confidence 0.41 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 0.51 Pain Relevance 0
As seen in Figure 3B, sirtinol had no effect on SIRT1-mediated neuronal survival.
Neg (no) Regulation (effect) of SIRT1 in neuronal
3) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.26 Pain Relevance 0.07
Treatment with this polyphenol induces deacetylation of known SIRT1 substrates such as NF-?
Regulation (deacetylation) of SIRT1
4) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.32 Pain Relevance 0.05
The present study tested the hypothesis that electroacupuncture (EA) ameliorates insulin sensitivity via regulation of SIRT1/PGC-1?
Regulation (regulation) of SIRT1 associated with electroacupuncture
5) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.60 Pain Relevance 0.43
SIRT1 immunoreactivity was normalized against the ?
Regulation (immunoreactivity) of SIRT1
6) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0 Pain Relevance 0.03
This is supported by a recent demonstration that SIRT1 levels were posttranscriptionally modified by phosphorylation of cell cycle-dependent kinase Cdk1 [21].

3.7.

Regulation (modified) of SIRT1
7) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.07 Pain Relevance 0.42
EA significantly increased SIRT1 protein levels in db/db and db/m mice (Figure 2), but it produced no significant effect on SIRT1 mRNA levels (Figure 3(a)).
Neg (no) Regulation (effect) of SIRT1 associated with electroacupuncture
8) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.13 Pain Relevance 0.42
Recent studies suggest an association between SIRT1 and insulin sensitivity [3].
Regulation (sensitivity) of SIRT1
9) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 1.24 Pain Relevance 0.05
Collectively, these findings indicate that therapy targeting SIRT1/PGC-1?
Regulation (targeting) of SIRT1
10) Confidence 0.26 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2964507 Disease Relevance 0.80 Pain Relevance 0.15
While the anti- and pro-survival effects of SIRT1, SIRT2, and SIRT3 were preserved in HT-22 cells, there were differences in the cases of SIRT5 and SIRT6.
Regulation (effects) of SIRT1
11) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.56 Pain Relevance 0.09
We next examined whether the effects observed with SIRT1, SIRT2, SIRT3, SIRT5, and SIRT6 on the regulation of LK-induced neuronal death extended to mouse HT-22 cells, a hippocampally-derived neuroblastoma cell line.
Regulation (regulation) of SIRT1 in neuronal associated with neuroblastoma and death
12) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605257 Disease Relevance 0.59 Pain Relevance 0
Sirt1 was also identified as a Foxl2 regulated gene that is activated by Foxl2 [18].
Regulation (regulated) of Sirt1
13) Confidence 0.15 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2831895 Disease Relevance 0.31 Pain Relevance 0
An awareness of mothers' specific needs is extremely important in order to modify information and breastfeeding support, and also to make appropriate clinical decisions and succeed with symptom management.
Regulation (modify) of information
14) Confidence 0.01 Published 2007 Journal BMC Health Serv Res Section Body Doc Link PMC2216017 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox