INT221415

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.73
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (IL10) DNA binding (IRF6) cell-cell signaling (IL10)
response to stress (IL10) cytoplasm (IRF6) cytosol (IRF6)
Anatomy Link Frequency
monocytes 3
alveolar macrophages 3
IRF6 (Homo sapiens)
IL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 8 97.28 Very High Very High Very High
cytokine 88 95.72 Very High Very High Very High
Inflammation 38 90.16 High High
tolerance 13 65.20 Quite High
Inflammatory stimuli 1 21.72 Low Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
lidocaine 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 4 91.04 High High
INFLAMMATION 43 90.16 High High
Immune Reconstitution Inflammatory Syndrome 31 84.08 Quite High
Mycobacterial Infection 100 81.80 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 35 81.68 Quite High
Injury 3 79.36 Quite High
Hypersensitivity 7 56.52 Quite High
Disease 7 54.12 Quite High
Infection 13 5.00 Very Low Very Low Very Low
Respiratory Disease 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Data from studies in normal human volunteers suggest that LPS increase the production of circulating IL-10, which would then blunt the proinflammatory response to a second bacterial challenge [60,61].
LPS Positive_regulation (increase) of Gene_expression (production) of IL-10
1) Confidence 0.05 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.14 Pain Relevance 0.27
This observation may find a mechanistic explanation in a study of human alveolar macrophages in which LPS-induced IL-10 production was associated with a reduced capacity to activate STAT3.
LPS Positive_regulation (induced) of Gene_expression (production) of IL-10 in alveolar macrophages
2) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.22 Pain Relevance 0.19
However, LPS induced higher production of IL-10 in monocytes than in bronchoalveolar cells suggesting that activation via TLR4 may result in differential cytokine production from alveolar macrophages and monocytes.
LPS Positive_regulation (induced) of Gene_expression (production) of IL-10 in monocytes associated with cytokine
3) Confidence 0.02 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.19 Pain Relevance 0.15
However, LPS induced higher production of IL-10 in monocytes than in bronchoalveolar cells suggesting that activation via TLR4 may result in differential cytokine production from alveolar macrophages and monocytes.
LPS Positive_regulation (induced) of in alveolar macrophages Gene_expression (production) of IL-10 in monocytes associated with cytokine
4) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.19 Pain Relevance 0.15

General Comments

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