INT221419

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 6.18
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (BRCA1) chromosome segregation (BRCA1) intracellular (BRCA1)
enzyme binding (BRCA1) DNA binding (BRCA1) protein complex (BRCA1)
Anatomy Link Frequency
dorsal 1
plasma 1
BRCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 99.20 Very High Very High Very High
tolerance 13 87.76 High High
Inflammation 36 75.00 Quite High
agonist 66 30.00 Quite Low
cINOD 15 5.00 Very Low Very Low Very Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 139 100.00 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 31 100.00 Very High Very High Very High
Osteogenic Sarcomas 158 99.70 Very High Very High Very High
Ovarian Cancer 8 99.70 Very High Very High Very High
Breast Cancer 160 98.88 Very High Very High Very High
Metastasis 30 94.28 High High
Bone Cancer 6 90.64 High High
Male Breast Neoplasms 2 85.40 High High
Disease 49 84.32 Quite High
Apoptosis 44 78.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Despite the strong contribution of BRCA1 to hereditary breast and ovarian cancer, mutations in BRCA1 do not account for all cases of inherited breast cancer, implicating the existence of a second major susceptibility gene.
Neg (not) Regulation (account) of BRCA1 associated with breast cancer and ovarian cancer
1) Confidence 0.35 Published 2010 Journal Current Genomics Section Body Doc Link PMC2878980 Disease Relevance 1.44 Pain Relevance 0
Thus, the anti-OS activity of VDR is dependent on many other nuclear proteins, including BRCA1 and RXRs.

11.

Regulation (dependent) of BRCA1 associated with osteogenic sarcomas
2) Confidence 0.18 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.91 Pain Relevance 0
Interestingly, it has been reported that the upregulation of VDR in OS cell lines is dependent on the tumor suppressor BRCA1 [202].
Regulation (dependent) of BRCA1 associated with cancer and osteogenic sarcomas
3) Confidence 0.15 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 1.67 Pain Relevance 0
The measure of microbial LPS, anti-LPS antibodies and nonspecific plasma cytokines in subjects on HAART shall predict the role of these components in IRIS.



Regulation (role) of IRIS in plasma associated with immune reconstitution inflammatory syndrome and cytokine
4) Confidence 0.13 Published 2007 Journal AIDS Res Ther Section Abstract Doc Link PMC2216023 Disease Relevance 1.03 Pain Relevance 0.31
Another modification, DiMeH3K27, showed increased levels in the ventral iris at day 2 and 6 after lentectomy, but the values in the dorsal iris during dedifferentiation were not higher than the ones in the intact dorsal iris.
Regulation (values) of iris in dorsal
5) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956703 Disease Relevance 0.15 Pain Relevance 0

General Comments

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