INT221422

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 12.63
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (BRCA1) chromosome segregation (BRCA1) intracellular (BRCA1)
enzyme binding (BRCA1) DNA binding (BRCA1) protein complex (BRCA1)
Anatomy Link Frequency
iris 2
dorsal 1
BRCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 242 100.00 Very High Very High Very High
cytokine 232 99.48 Very High Very High Very High
Central nervous system 108 77.68 Quite High
Inflammatory response 40 44.40 Quite Low
fibrosis 6 39.48 Quite Low
tolerance 13 5.00 Very Low Very Low Very Low
Neuritis 12 5.00 Very Low Very Low Very Low
headache 12 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immune Reconstitution Inflammatory Syndrome 1363 100.00 Very High Very High Very High
INFLAMMATION 256 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 320 99.84 Very High Very High Very High
Death 104 99.80 Very High Very High Very High
Mycobacterial Infection 55 99.68 Very High Very High Very High
Infection 73 99.64 Very High Very High Very High
Cryptococcal Meningitis 612 92.84 High High
Repression 9 91.72 High High
Eosinophilia 6 88.84 High High
General Immunology 8 83.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preliminary investigations have shown that an acute exacerbation of mycobacteria-specific Th1 response after HIV infection control by HAART causes IRIS in HIV/TB [17,18].


Positive_regulation (causes) of IRIS associated with mycobacterial infection, immune reconstitution inflammatory syndrome, acquired immune deficiency syndrome or hiv infection and infection
1) Confidence 0.23 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 2.55 Pain Relevance 0.04
Overall, our data suggest that Th2 responses to cryptococcus are associated with poor outcomes, including increased risk for IRIS and death.
Positive_regulation (increased) of IRIS associated with immune reconstitution inflammatory syndrome and death
2) Confidence 0.12 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.31 Pain Relevance 0.03
At time of cryptococcal IRIS, serum biomarkers of inflammation were elevated in almost all IRIS patients over those in time-matched controls (Table 4).
Positive_regulation (elevated) of cryptococcal IRIS associated with immune reconstitution inflammatory syndrome and inflammation
3) Confidence 0.09 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.80 Pain Relevance 0.34
The anti-inflammatory mediator IL-1RA increased following ART initiation and before IRIS.
Positive_regulation (increased) of IRIS associated with immune reconstitution inflammatory syndrome and inflammation
4) Confidence 0.09 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.69 Pain Relevance 0.34
After starting HIV therapy, increasing levels of the inflammatory proteins C-reactive protein and D-dimer, and of several cytokines, were associated with an increased risk of IRIS.
Positive_regulation (increased) of IRIS associated with immune reconstitution inflammatory syndrome, inflammation, acquired immune deficiency syndrome or hiv infection and cytokine
5) Confidence 0.08 Published 2010 Journal PLoS Medicine Section Abstract Doc Link PMC3014618 Disease Relevance 2.28 Pain Relevance 0.32
IL-6 was most frequently elevated at time of IRIS events (median 5-fold increase compared with time-matched control participants).
Positive_regulation (increase) of IRIS associated with immune reconstitution inflammatory syndrome
6) Confidence 0.08 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 1.87 Pain Relevance 0.41
or VEGF were associated with increased IRIS risk.
Positive_regulation (increased) of IRIS associated with immune reconstitution inflammatory syndrome
7) Confidence 0.08 Published 2010 Journal PLoS Medicine Section Body Doc Link PMC3014618 Disease Relevance 0.81 Pain Relevance 0.05
Although in the dorsal iris TriMeH3K27 was kept at same levels after lentectomy, in ventral iris it was increased.


Positive_regulation (increased) of iris in iris
8) Confidence 0.01 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2956703 Disease Relevance 0.09 Pain Relevance 0
Although levels were not much changed in dorsal iris, they increased in ventral iris.
Positive_regulation (increased) of iris in iris
9) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956703 Disease Relevance 0.09 Pain Relevance 0
Another modification, DiMeH3K27, showed increased levels in the ventral iris at day 2 and 6 after lentectomy, but the values in the dorsal iris during dedifferentiation were not higher than the ones in the intact dorsal iris.
Positive_regulation (increased) of iris in dorsal
10) Confidence 0.01 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2956703 Disease Relevance 0.14 Pain Relevance 0

General Comments

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