INT221423

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.09
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CD14) extracellular region (CD14) plasma membrane (CD14)
Anatomy Link Frequency
monocytes 4
macrophages 2
CD14 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 13 99.70 Very High Very High Very High
anesthesia 34 96.00 Very High Very High Very High
cytokine 24 95.76 Very High Very High Very High
Inflammation 46 93.92 High High
antagonist 8 45.60 Quite Low
chemokine 2 29.68 Quite Low
Neurotransmitter 2 9.68 Low Low
Inflammatory response 16 5.00 Very Low Very Low Very Low
cva 7 5.00 Very Low Very Low Very Low
Enkephalin 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 67 98.84 Very High Very High Very High
Dengue 63 98.16 Very High Very High Very High
INFLAMMATION 55 93.92 High High
Sepsis 20 93.80 High High
Infection 49 89.68 High High
Stress 13 86.88 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 33 85.08 High High
Mycobacterial Infection 19 83.40 Quite High
Immune Reconstitution Inflammatory Syndrome 31 58.00 Quite High
Injury 13 11.76 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deciphering the acting mediators associated with HLA-DR down-regulation on CD14HIGH and CD14LOW monocytes
Negative_regulation (-) of Negative_regulation (regulation) of CD14HIGH in monocytes
1) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.29
Deciphering the acting mediators associated with HLA-DR down-regulation on CD14HIGH and CD14LOW monocytes
Negative_regulation (down) of Negative_regulation (regulation) of CD14HIGH in monocytes
2) Confidence 0.31 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.29
This was consistent with the study by de Kruif et al. [37], who found that CD14 was down-regulated in Indonesian children with DSS, relative to DF and DHF cases.
Negative_regulation (down) of Negative_regulation (regulated) of CD14 associated with dengue and dengue hemorrhagic fever
3) Confidence 0.30 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 1.32 Pain Relevance 0
A potential mechanism whereby endotoxin-tolerance develops is a down-regulation of LPS receptors such as membrane CD14 on macrophages [70].
Negative_regulation (down) of Negative_regulation (regulation) of CD14 in macrophages associated with tolerance
4) Confidence 0.29 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.60 Pain Relevance 0.42

General Comments

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