INT221426

Context Info Confidence 0.48 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 9 Disease Relevance 5.98 Pain Relevance 1.72

growth (FOXP3) nucleus (FOXP3) intracellular (FOXP3) embryo development (FOXP3) protein complex (FOXP3) cytoplasm (FOXP3)

Anatomy Link Frequency naive T-cells 2 regulatory T cells 2 FOXP3 (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 55 100.00 agonist 2 98.24 Arthritis 36 97.50 Inflammation 163 90.64 cytokine 163 90.56 Inflammatory response 7 89.28 rheumatoid arthritis 89 84.88 chemokine 18 79.00 Crohn's disease 8 66.48 methotrexate 7 41.60

Disease Link Frequency Relevance Heat Immune Reconstitution Inflammatory Syndrome 31 100.00 Disease 111 99.56 Systemic Lupus Erythematosus 26 97.64 Juvenile Chronic Polyarthritis 32 97.50 Mycobacterial Infection 19 96.08 Glioma 34 95.00 Diarrhoea 2 93.24 Infection 10 91.48 INFLAMMATION 163 90.64 Hypersensitivity 10 90.56

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Opposite findings of increased Foxp3 expression in active disease were reported in one study of pediatric SLE [133].

Positive_regulation (increased) of Gene_expression (expression) of Foxp3 associated with systemic lupus erythematosus and disease

1) Confidence 0.48 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 1.27 Pain Relevance 0.06

In another study of synovial CD4+CD25high regulatory T cells in persistent and extended oligoarticular JIA, Massa et al. demonstrated that certain epitopes of human HSP increase the frequency of CD4+CD25high regulatory T cells and induce Foxp3 expression [109].

Positive_regulation (induce) of Gene_expression (expression) of Foxp3 in regulatory T cells associated with arthritis

2) Confidence 0.48 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.79 Pain Relevance 0.35

induced FOXP3 expression.

Positive_regulation (induced) of Gene_expression (expression) of FOXP3

3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.08 Pain Relevance 0.07

induced FOXP3 expression in this setting (p?

Positive_regulation (induced) of Gene_expression (expression) of FOXP3

4) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806834 Disease Relevance 0.42 Pain Relevance 0.42

The likelihood of 'normal' FOXP3+ gene and endotoxin-tolerance among IRIS non-developers – Why?

Positive_regulation (tolerance) of Gene_expression (non) of FOXP3 associated with immune reconstitution inflammatory syndrome and tolerance

5) Confidence 0.36 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.96 Pain Relevance 0.31

Elias et al. have shown that all-trans retinoic acid (ATRA) and other agonists of the retinoic acid receptor alpha (RARalpha) inhibit the formation of TH17 cells and promote FoxP3 expression [95], while Benson et al. have reported that ATRA enhances Treg growth and differentiation [96].

Positive_regulation (promote) of Gene_expression (expression) of FoxP3 associated with agonist

6) Confidence 0.33 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.74 Pain Relevance 0.17

A further evidence of the importance of FoxP3 derives from the observation by Hori et al. that retroviral gene transfer of FoxP3 converts naive T-cells into a regulatory T cell phenotype similar to that of naturally occurring CD4+ regulatory T-cells [20].

Positive_regulation (transfer) of Gene_expression (transfer) of FoxP3 in naive T-cells

7) Confidence 0.33 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.93 Pain Relevance 0.11

Although p-STAT-3 may be a transcriptional factor related to induction of FoxP3 expression, it may not be the only factor that influences Treg generation.

Positive_regulation (induction) of Gene_expression (expression) of FoxP3

8) Confidence 0.32 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.31 Pain Relevance 0.07

There are several reports about Foxp3, ROR?

Positive_regulation (several) of Gene_expression (several) of Foxp3

9) Confidence 0.23 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2950393 Disease Relevance 0.47 Pain Relevance 0.15

General Comments

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