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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.74
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

growth (FOXP3) nucleus (FOXP3) intracellular (FOXP3)
embryo development (FOXP3) protein complex (FOXP3) cytoplasm (FOXP3)
Anatomy Link Frequency
regulatory T cells 1
T-cells 1
FOXP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 34 100.00 Very High Very High Very High
cytokine 75 98.92 Very High Very High Very High
Arthritis 18 96.36 Very High Very High Very High
Inflammation 81 90.16 High High
chemokine 10 79.00 Quite High
methotrexate 3 65.60 Quite High
corticosteroid 3 64.24 Quite High
dexamethasone 3 25.56 Quite Low
rheumatoid arthritis 10 22.24 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Immune Reconstitution Inflammatory Syndrome 31 99.72 Very High Very High Very High
Cancer 84 98.02 Very High Very High Very High
Juvenile Chronic Polyarthritis 16 96.36 Very High Very High Very High
Mycobacterial Infection 100 96.08 Very High Very High Very High
INFLAMMATION 82 90.16 High High
Sepsis 4 88.36 High High
Glioma 34 64.20 Quite High
Sprains And Strains 18 64.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 47 63.40 Quite High
Injury 3 61.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These included evidence of an early Th2 dominant microenvironment, with subsequent accumulation of eosinophils and FoxP3+ T-cells.
Positive_regulation (accumulation) of FoxP3 in T-cells
1) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.24 Pain Relevance 0.04
The likelihood of 'normal' FOXP3+ gene and endotoxin-tolerance among IRIS non-developers – Why?
Positive_regulation (tolerance) of FOXP3 associated with immune reconstitution inflammatory syndrome and tolerance
2) Confidence 0.36 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.96 Pain Relevance 0.31
They found that CD4+CD25high regulatory T cells expressing surface CD27 exhibit a higher level of Foxp3 and have stronger suppressive activity.
Positive_regulation (level) of Foxp3 in regulatory T cells
3) Confidence 0.35 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.56 Pain Relevance 0.35
Tumor-associated Tregs express the IL-23 receptor, which activates STAT-3 in this cell type, leading to upregulation of the Treg-specific transcription factor FoxP3 and the immunosuppressive cytokine IL-10 [47].
Positive_regulation (upregulation) of FoxP3 associated with cancer and cytokine
4) Confidence 0.32 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.57 Pain Relevance 0.09
It is worth noting that induction of FoxP3 is also under the control of TCR and CD28 signaling.
Positive_regulation (induction) of FoxP3
5) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.28 Pain Relevance 0.06
Potential accumulation of transcription factor binding sites (FOXP3, GR, PR A/PR B) may occur, depending on the number of tetranucleotide repeats.
Positive_regulation (accumulation) of FOXP3
6) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2735778 Disease Relevance 0.13 Pain Relevance 0

General Comments

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