INT221427

Context Info Confidence 0.45 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 2.74 Pain Relevance 0.83

growth (FOXP3) nucleus (FOXP3) intracellular (FOXP3) embryo development (FOXP3) protein complex (FOXP3) cytoplasm (FOXP3)

Anatomy Link Frequency regulatory T cells 1 T-cells 1 FOXP3 (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 34 100.00 cytokine 75 98.92 Arthritis 18 96.36 Inflammation 81 90.16 chemokine 10 79.00 methotrexate 3 65.60 corticosteroid 3 64.24 dexamethasone 3 25.56 rheumatoid arthritis 10 22.24 Central nervous system 7 5.00

Disease Link Frequency Relevance Heat Immune Reconstitution Inflammatory Syndrome 31 99.72 Cancer 84 98.02 Juvenile Chronic Polyarthritis 16 96.36 Mycobacterial Infection 100 96.08 INFLAMMATION 82 90.16 Sepsis 4 88.36 Glioma 34 64.20 Sprains And Strains 18 64.16 Acquired Immune Deficiency Syndrome Or Hiv Infection 47 63.40 Injury 3 61.08

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Event

Anatomy

Negation

Speculation

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Disease term

These included evidence of an early Th2 dominant microenvironment, with subsequent accumulation of eosinophils and FoxP3+ T-cells.

Positive_regulation (accumulation) of FoxP3 in T-cells

1) Confidence 0.45 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.24 Pain Relevance 0.04

The likelihood of 'normal' FOXP3+ gene and endotoxin-tolerance among IRIS non-developers – Why?

Positive_regulation (tolerance) of FOXP3 associated with immune reconstitution inflammatory syndrome and tolerance

2) Confidence 0.36 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.96 Pain Relevance 0.31

They found that CD4+CD25high regulatory T cells expressing surface CD27 exhibit a higher level of Foxp3 and have stronger suppressive activity.

Positive_regulation (level) of Foxp3 in regulatory T cells

3) Confidence 0.35 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2633304 Disease Relevance 0.56 Pain Relevance 0.35

Tumor-associated Tregs express the IL-23 receptor, which activates STAT-3 in this cell type, leading to upregulation of the Treg-specific transcription factor FoxP3 and the immunosuppressive cytokine IL-10 [47].

Positive_regulation (upregulation) of FoxP3 associated with cancer and cytokine

4) Confidence 0.32 Published 2009 Journal J Transl Med Section Body Doc Link PMC2777138 Disease Relevance 0.57 Pain Relevance 0.09

It is worth noting that induction of FoxP3 is also under the control of TCR and CD28 signaling.

Positive_regulation (induction) of FoxP3

5) Confidence 0.30 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2821644 Disease Relevance 0.28 Pain Relevance 0.06

Potential accumulation of transcription factor binding sites (FOXP3, GR, PR A/PR B) may occur, depending on the number of tetranucleotide repeats.

Positive_regulation (accumulation) of FOXP3

6) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2735778 Disease Relevance 0.13 Pain Relevance 0

General Comments

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