INT221428

Context Info Confidence 0.35 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.97 Pain Relevance 0.70

growth (FOXP3) nucleus (FOXP3) intracellular (FOXP3) embryo development (FOXP3) protein complex (FOXP3) cytoplasm (FOXP3)

FOXP3 (Homo sapiens)

Pain Link Frequency Relevance Heat tolerance 26 95.84 Inflammatory response 8 94.04 Inflammation 40 90.32 cytokine 32 86.04 chemokine 4 73.44 corticosteroid 2 67.28 cINOD 2 64.64 Inflammatory stimuli 2 5.00

Disease Link Frequency Relevance Heat Immune Reconstitution Inflammatory Syndrome 62 99.48 Mycobacterial Infection 38 95.32 Acquired Immune Deficiency Syndrome Or Hiv Infection 64 95.20 INFLAMMATION 44 93.64 Sepsis 8 82.80 Injury 6 55.52 Hypersensitivity 2 32.68 Disease 14 30.28 Infection 14 5.00 Death 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This 'paradoxical worsening' could also be attributable to additional presence of defective FOXP3+ gene among IRIS developers.

Negative_regulation (presence) of Negative_regulation (defective) of FOXP3 associated with immune reconstitution inflammatory syndrome

1) Confidence 0.35 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 1.07 Pain Relevance 0.41

This 'paradoxical worsening' could also be attributable to additional presence of defective FOXP3+ gene among IRIS developers.

Negative_regulation (presence) of Negative_regulation (defective) of FOXP3 associated with immune reconstitution inflammatory syndrome

2) Confidence 0.35 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.90 Pain Relevance 0.28

General Comments

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