INT22143

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Context Info
Confidence 0.76
First Reported 1990
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 35
Total Number 43
Disease Relevance 14.40
Pain Relevance 15.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gad1) lyase activity (Gad1) intracellular (Gad1)
cytoplasm (Gad1)
Anatomy Link Frequency
neurons 5
brain 4
basal ganglia 2
embryonic brains 2
serotonin neurons 2
Gad1 (Mus musculus)
Gad1 - S12C (1)
Pain Link Frequency Relevance Heat
gABA 681 100.00 Very High Very High Very High
GABAergic 304 100.00 Very High Very High Very High
Glutamate 229 100.00 Very High Very High Very High
Enkephalin 23 100.00 Very High Very High Very High
Kinase C 14 100.00 Very High Very High Very High
substance P 12 100.00 Very High Very High Very High
Serotonin 21 99.82 Very High Very High Very High
narcan 2 99.74 Very High Very High Very High
amygdala 83 99.40 Very High Very High Very High
Dopamine 14 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 510 100.00 Very High Very High Very High
Ganglion Cysts 261 100.00 Very High Very High Very High
Generalized Anxiety Disorder 155 99.92 Very High Very High Very High
Aids-related Complex 135 98.76 Very High Very High Very High
Urological Neuroanatomy 16 98.52 Very High Very High Very High
Apoptosis 19 98.20 Very High Very High Very High
Aggression 8 97.90 Very High Very High Very High
Opiate Addiction 5 97.44 Very High Very High Very High
Ataxia 35 96.32 Very High Very High Very High
Congenital Anomalies 52 96.16 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We are now expressing the variant forms of GAD67 (S12C) and GAD25 (S12C), as recombinant proteins, to assess catalytic activity and binding properties with respect to their normal counterparts.
Gene_expression (expressing) of GAD25
1) Confidence 0.76 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.46 Pain Relevance 0
There is also evidence for a 25 kDa inactive protein (GAD25) produced from an alternatively spliced GAD1 transcript of 2 kb that contains an in-frame stop codon.
Gene_expression (produced) of GAD25
2) Confidence 0.76 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.30 Pain Relevance 0.21
Bond et al. [27] showed that GAD25 is expressed in a temporally controlled manner, in the developing striatum and cortex in rodents, suggesting this may provide a mechanism of regulating GABA production in differentiating neurons.
Gene_expression (expressed) of GAD25 in neurons associated with gaba
3) Confidence 0.76 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.23 Pain Relevance 0.26
We are now expressing the variant forms of GAD67 (S12C) and GAD25 (S12C), as recombinant proteins, to assess catalytic activity and binding properties with respect to their normal counterparts.
Gene_expression (expressing) of GAD67 (S12C)
4) Confidence 0.76 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.46 Pain Relevance 0
Our Western blot analysis showed that the expression levels of both GAD65 and GAD67 in VGAT+/+ and VGAT-/- brains were similar (Figure 2B).
Gene_expression (expression) of GAD67 in brains
5) Confidence 0.75 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.21 Pain Relevance 0.62
Two isozymes of GAD, GAD65 and GAD67, are primarily expressed in GABAergic neurons [4,5].
Gene_expression (expressed) of GAD67 in GABAergic neurons associated with generalized anxiety disorder and gabaergic
6) Confidence 0.75 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.88 Pain Relevance 0.70
Conversely, the amounts of the GABA-synthesizing enzymes GAD65 and GAD67 were not different in between the brains of VGAT-/- mice and their control littermates (Figure 2B).
Gene_expression (synthesizing) of GAD67 in brains associated with gaba
7) Confidence 0.75 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.24 Pain Relevance 0.60
To test for this possibility, we analyzed the expression levels of GAD65 and GAD67 in the embryonic brains.
Spec (analyzed) Gene_expression (expression) of GAD67 in embryonic brains
8) Confidence 0.75 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.22 Pain Relevance 0.60
The migratory neuroblast and GABAergic phenotype of periglomerular cells was reflected in the expression of Dcx [14] (immature neurons) and Gad1 [15] (GAD67 protein in GABAergic interneurons), respectively.
Gene_expression (expression) of Gad1 in interneurons associated with gabaergic
9) Confidence 0.68 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2063466 Disease Relevance 0 Pain Relevance 0.10
There is also evidence for a 25 kDa inactive protein (GAD25) produced from an alternatively spliced GAD1 transcript of 2 kb that contains an in-frame stop codon.
Gene_expression (produced) of GAD1
10) Confidence 0.66 Published 2004 Journal BMC Neurol Section Body Doc Link PMC544830 Disease Relevance 0.29 Pain Relevance 0.21
In SI male mice, aggression can be prevented by treatment with L-methionine (MET), which has also been shown to decrease reelin and GAD67 mRNA expression and maintain normal brain Allo content.
Gene_expression (expression) of GAD67 in brain associated with aggression
11) Confidence 0.65 Published 2004 Journal Crit Rev Neurobiol Section Abstract Doc Link 15581402 Disease Relevance 0.66 Pain Relevance 0.07
neo) (GAD67GFP/GFP) mice as GAD67 knockout (GAD67-/-) mice.
Gene_expression (knockout) of GAD67 associated with targeted disruption
12) Confidence 0.65 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.36 Pain Relevance 0.03
The generation of the GAD67-GFP (?
Gene_expression (generation) of GAD67
13) Confidence 0.65 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.36 Pain Relevance 0.04
Phenotypes of VGAT and GAD67 knockouts outside of the brain
Gene_expression (knockouts) of GAD67 in brain
14) Confidence 0.65 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 1.08 Pain Relevance 0.09
neo) (GAD67GFP/GFP) mice as GAD67 knockout (GAD67-/-) mice.
Gene_expression (knockout) of GAD67 associated with targeted disruption
15) Confidence 0.65 Published 2010 Journal Mol Brain Section Body Doc Link PMC3023674 Disease Relevance 0.36 Pain Relevance 0.03
Cell counts in the GCL showed that 12.4% and 9.2% of the CFP-containing cells in the GCL expressed GAD67 and GAT-1 immunoreactivity, respectively (Table 1).
Gene_expression (expressed) of GAD67
16) Confidence 0.64 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.05 Pain Relevance 0.08
The expression of GAD67 and GAT-1 were evaluated in the thy1-CFP mouse retina.
Gene_expression (expression) of GAD67 in retina
17) Confidence 0.64 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.13 Pain Relevance 0.09
In our study, all CFP-containing amacrine cells in the INL were GABAergic based on their expression of the GABA synthetic enzyme GAD67 or the high affinity plasma membrane GABA transporter, GAT-1 [37,51-55,65].
Gene_expression (expression) of GAD67 in plasma associated with gaba and gabaergic
18) Confidence 0.64 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.07 Pain Relevance 0.24
Striatal expression of substance P and enkephalin mRNAs was reduced by about 50% and 30%, respectively, whereas the expression of GAD67 and GAD65 mRNAs was slightly increased and unaltered, respectively.
Gene_expression (expression) of GAD67 associated with enkephalin and substance p
19) Confidence 0.61 Published 2001 Journal J. Neurochem. Section Abstract Doc Link 11432985 Disease Relevance 0.09 Pain Relevance 0.65
Enhanced Fos expression in glutamic acid decarboxylase immunoreactive neurons of the mouse periaqueductal grey during opioid withdrawal.
Gene_expression (expression) of glutamic acid decarboxylase in neurons associated with narcan, withdrawal, opioid and central grey
20) Confidence 0.60 Published 2006 Journal Neuroscience Section Title Doc Link 16359817 Disease Relevance 0.75 Pain Relevance 1.21

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