INT221433

Context Info Confidence 0.11 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 4.74 Pain Relevance 1.70

nucleoplasm (NFKB2) extracellular matrix organization (NFKB2) DNA binding (NFKB2) cytoplasm (NFKB2) cytosol (NFKB2) signal transduction (NFKB2)

Anatomy Link Frequency T-cells 1 NFKB2 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 139 99.96 cytokine 71 99.26 Inflammatory stimuli 2 96.32 methotrexate 6 94.32 fibrosis 58 92.32 Analgesic 3 85.68 Piles 3 78.48 Inflammatory response 9 41.84 Pain 6 20.20 tolerance 26 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 145 99.96 Mucositis 165 99.92 Biliary Atresia 19 99.84 Injury 74 95.52 Mycobacterial Infection 38 93.32 Fibrosis 58 92.32 Apoptosis 20 85.88 Stress 3 85.00 Anorectal Disorders 3 78.48 Disease 47 76.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

NFkB resides in the cytoplasm and is bound to its inhibitor.

NFkB Binding (bound) of

1) Confidence 0.11 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.76 Pain Relevance 0.28

Cytokines such as IL-1 can also stimulate the NFkB binding molecule to activate NFkB [54-56], which induces the expression of cyclooxygenase-2 (COX-2), which consequently leads to tissue inflammation at the site where latent TB antigens are located.

NFkB Binding (binding) of associated with mycobacterial infection, inflammation and cytokine

2) Confidence 0.09 Published 2007 Journal AIDS Res Ther Section Body Doc Link PMC2216023 Disease Relevance 0.86 Pain Relevance 0.23

Treatment with NFkB inhibitors has been shown

NFkB Binding (Treatment) of

3) Confidence 0.05 Published 2008 Journal Journal of Oncology Section Body Doc Link PMC2648637 Disease Relevance 0.85 Pain Relevance 0.27

mediators, TNF and NFkB, have been shown to increase along the length of the

NFkB Binding (mediators) of

4) Confidence 0.05 Published 2008 Journal Journal of Oncology Section Body Doc Link PMC2648637 Disease Relevance 0.72 Pain Relevance 0.30

These include NFkB signalling, complement and coagulation cascades,

NFkB Binding (complement) of

5) Confidence 0.05 Published 2008 Journal Journal of Oncology Section Body Doc Link PMC2648637 Disease Relevance 0.96 Pain Relevance 0.44

Among these transcription factors we highlight the sites for nuclear factor of activated T-cells (NFAT; 65 genes, P < 0.001) and nuclear factor (NF)kB (60 genes, P < 0.001; Figure 6a; Additional file 6) because both regulate immunity genes, but only the pleiotropic transcription factor NFkB being previously linked to biliary atresia [29,30].

NFkB Binding (linked) of in T-cells associated with biliary atresia

6) Confidence 0.02 Published 2010 Journal Genome Med Section Body Doc Link PMC2887077 Disease Relevance 0.59 Pain Relevance 0.18

General Comments

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