INT221448

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 27
Disease Relevance 27.44
Pain Relevance 10.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CREG1) oxidoreductase activity (CREG1) extracellular region (CREG1)
transcription factor binding (CREG1)
Anatomy Link Frequency
joint 2
plasma 1
external 1
internal 1
CREG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1920 100.00 Very High Very High Very High
Inflammation 480 100.00 Very High Very High Very High
Osteoarthritis 960 99.88 Very High Very High Very High
methotrexate 20 99.40 Very High Very High Very High
Chronic pancreatitis 56 98.48 Very High Very High Very High
cINOD 20 97.40 Very High Very High Very High
cytokine 280 93.60 High High
metalloproteinase 40 55.52 Quite High
fibrosis 60 55.36 Quite High
chemokine 40 46.00 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1920 100.00 Very High Very High Very High
INFLAMMATION 480 100.00 Very High Very High Very High
Disease 315 100.00 Very High Very High Very High
Frailty 980 99.88 Very High Very High Very High
Pancreatic Cancer 140 99.64 Very High Very High Very High
Arthropathy 40 99.64 Very High Very High Very High
Pancreatitis 63 98.48 Very High Very High Very High
Hypersensitivity 40 98.40 Very High Very High Very High
Glioma 40 97.36 Very High Very High Very High
Apoptosis 280 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The "genes expressed in" module lists the genes expressed in the tissue types defined in the pancreatic specimen/cell module, irrespective of their mode of regulation (whether they are differentially expressed or not).
Gene_expression (expressed) of genes
1) Confidence 0.05 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2216037 Disease Relevance 1.38 Pain Relevance 0.46
Using the Pancreatic Expression database, it is possible to search and retrieve genes/proteins expressed only in pancreatic cancer and not in chronic pancreatitis and then ask which of these are present in urine and/or plasma.
Neg (not) Gene_expression (expressed) of genes in plasma associated with pancreatic cancer and chronic pancreatitis
2) Confidence 0.05 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2216037 Disease Relevance 0.53 Pain Relevance 0.10
The "genes expressed in" module lists the genes expressed in the tissue types defined in the pancreatic specimen/cell module, irrespective of their mode of regulation (whether they are differentially expressed or not).
Gene_expression (expressed) of genes
3) Confidence 0.05 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2216037 Disease Relevance 1.37 Pain Relevance 0.46
All selected genes are presented in Supplementary Table 1 (sorted according to absolute variance-fold values).
Gene_expression (presented) of genes
4) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 0.91 Pain Relevance 0.52
This analysis did not concentrate on differently expressed genes, but on genes with different variances in the three patient groups [30].
Gene_expression (expressed) of genes
5) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 0.11 Pain Relevance 0.06
[82], or MMP-1 [83], elevated or reduced expression levels of many different genes in various pathways/complexes may also influence RA development and progression.
Gene_expression (expression) of genes associated with rheumatoid arthritis
6) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.22 Pain Relevance 0.57
It has been hypothesized that expression variances of regulatory key genes contribute to the individual phenotype of the given disease [17], whether independent of or depending on the expression level.
Gene_expression (expression) of genes associated with disease
7) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.43 Pain Relevance 0.53
Interestingly, the respective genes in this particular pathway also show increased expression levels in RA SM (data not shown).
Gene_expression (expression) of genes associated with rheumatoid arthritis
8) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.33 Pain Relevance 0.40
Using these criteria, 568 genes were selected for the comparison between RA and NC (307 with higher variances in RA and 261 with higher variances in NC) while 542 genes were used for the comparison OA versus NC (314 with higher variances in OA and 228 with higher variances in NC).
Gene_expression (selected) of genes associated with rheumatoid arthritis and osteoarthritis
9) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 0.87 Pain Relevance 0.52
Possible external reasons may include the higher average age of the individuals in the RA group as well as medication influencing immunological processes and the expression of immunologically relevant genes (for example, methotrexate, prednisolone, sulfasalazine, and/or nonsteroidal anti-inflammatory drugs [35,36]) or differences in nutrition, with general effects on individual gene expression [37].
Gene_expression (expression) of genes in external associated with inflammation, cinod, rheumatoid arthritis and methotrexate
10) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.27 Pain Relevance 0.53
In this process, the affection of pathologically relevant pathways with differentially expressed genes may be more important than the character of the respective genes, resulting in different gene expression profiles among individual RA patients as reflected in the gene expression variances of the present study.
Gene_expression (expressed) of genes associated with rheumatoid arthritis
11) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.12 Pain Relevance 0.53
In RA, differences in gene expression profiles for specific genes among two subgroups of RA patients have been reported, but within these subgroups, the differences are limited to distinct expression levels without significant intra-subgroup expression variances [12].
Gene_expression (expression) of genes associated with rheumatoid arthritis
12) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.11 Pain Relevance 0.23
This analysis did not concentrate on differently expressed genes, but on genes with different variances in the three patient groups [30].
Gene_expression (expressed) of genes
13) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 0.11 Pain Relevance 0.06
Relevant genes were selected using different criteria: (a) a significance level of P ?
Gene_expression (selected) of genes
14) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 0.54 Pain Relevance 0.36
It has been hypothesized that expression variances of regulatory key genes contribute to the individual phenotype of the given disease [17], whether independent of or depending on the expression level.
Gene_expression (expression) of genes associated with disease
15) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 1.40 Pain Relevance 0.53
Using these criteria, 568 genes were selected for the comparison between RA and NC (307 with higher variances in RA and 261 with higher variances in NC) while 542 genes were used for the comparison OA versus NC (314 with higher variances in OA and 228 with higher variances in NC).
Gene_expression (used) of genes associated with rheumatoid arthritis and osteoarthritis
16) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575612 Disease Relevance 0.92 Pain Relevance 0.53
Thus a wealth of information regarding mutated and aberrantly expressed genes, miRNAs and proteins is now available, not only significantly boosting our biological understanding of the disease but also helping to identify new (early) diagnostic and therapeutic targets.
Gene_expression (expressed) of genes associated with disease
17) Confidence 0.04 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2216037 Disease Relevance 0.66 Pain Relevance 0
In order to achieve this, we designed a robust internal structure encompassing specific pre-defined modules (which can be found under the "Filters" section in the database) including "pancreatic specimen/cell type", "pancreatic differential expression information", "genes differentially expressed in" and "genes expressed in" modules.
Gene_expression (expressed) of genes in internal
18) Confidence 0.04 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2216037 Disease Relevance 0.26 Pain Relevance 0
The "genes expressed in" module lists the genes expressed in the tissue types defined in the pancreatic specimen/cell module, irrespective of their mode of regulation (whether they are differentially expressed or not).
Gene_expression (expressed) of genes
19) Confidence 0.04 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2216037 Disease Relevance 1.35 Pain Relevance 0.46
The "genes expressed in" module lists the genes expressed in the tissue types defined in the pancreatic specimen/cell module, irrespective of their mode of regulation (whether they are differentially expressed or not).
Gene_expression (expressed) of genes
20) Confidence 0.04 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2216037 Disease Relevance 1.38 Pain Relevance 0.46

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