INT22145

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Context Info
Confidence 0.13
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 8.31
Pain Relevance 4.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
quadriceps 1
neurons 1
striatum 1
prefrontal 1
body 1
Sugt1 (Mus musculus)
Pain Link Frequency Relevance Heat
cannabis 42 99.80 Very High Very High Very High
alcohol 21 99.76 Very High Very High Very High
Opioid 133 99.68 Very High Very High Very High
Pain 7 99.56 Very High Very High Very High
addiction 158 99.48 Very High Very High Very High
Inflammation 18 98.60 Very High Very High Very High
sSRI 91 98.52 Very High Very High Very High
Hippocampus 20 97.56 Very High Very High Very High
Catechol-O-methyltransferase 54 95.76 Very High Very High Very High
Glutamate 1 94.72 High High
Disease Link Frequency Relevance Heat
Opiate Addiction 168 99.76 Very High Very High Very High
Alcohol Addiction 7 99.76 Very High Very High Very High
Pain 7 99.56 Very High Very High Very High
Body Weight 18 99.40 Very High Very High Very High
Stress 10 99.20 Very High Very High Very High
INFLAMMATION 24 98.60 Very High Very High Very High
Nicotine Addiction 24 98.32 Very High Very High Very High
Disease 20 98.08 Very High Very High Very High
Death 4 97.80 Very High Very High Very High
Cardiovascular Disease 15 97.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that the Lc allele probably does not interfere with the developmental program but acts to cause cell death in already differentiated Purkinje neurons.
Lc allele Neg (not) Binding (interfere) of in neurons associated with death
1) Confidence 0.13 Published 1990 Journal J. Neurosci. Res. Section Abstract Doc Link 2254957 Disease Relevance 0.10 Pain Relevance 0.05
1) The associations found could be related more to the progression and severity of heroin dependence than vulnerability to this disorder [28], because patients had a long history of heroin use; 2) Type II error is a potential explanation for our findings, since the differences detected did not reach the significance threshold (i.e.: P < 0.008) when the Bonferroni correction was applied to the six genetic comparisons performed (Tables 2 and 3); however, type II error could occur in any direction (i.e., either A1 or A2 could have been associated with heroin use), while we found that the associated allele was A1, just as in previous reports; 3) The male-limited association of A1 allele with heroin dependence must be considered as a preliminary finding, because more males than females participated in the present study and there is no indication of gender dimorphism in regard with the TaqI A alleles in the literature; 4) The findings of the present study may not be generalizable, because all study participants belonged to the same population.
allele Binding (association) of associated with addiction and opiate addiction
2) Confidence 0.06 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.57 Pain Relevance 0.27
1) The associations found could be related more to the progression and severity of heroin dependence than vulnerability to this disorder [28], because patients had a long history of heroin use; 2) Type II error is a potential explanation for our findings, since the differences detected did not reach the significance threshold (i.e.: P < 0.008) when the Bonferroni correction was applied to the six genetic comparisons performed (Tables 2 and 3); however, type II error could occur in any direction (i.e., either A1 or A2 could have been associated with heroin use), while we found that the associated allele was A1, just as in previous reports; 3) The male-limited association of A1 allele with heroin dependence must be considered as a preliminary finding, because more males than females participated in the present study and there is no indication of gender dimorphism in regard with the TaqI A alleles in the literature; 4) The findings of the present study may not be generalizable, because all study participants belonged to the same population.
allele Binding (associated) of associated with addiction and opiate addiction
3) Confidence 0.05 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.57 Pain Relevance 0.31
Male-limited associations of the DRD2 A1 allele with alcohol dependence [26] and tobacco smoking [27] have been reported previously.
allele Binding (associations) of associated with addiction, nicotine addiction and alcohol
4) Confidence 0.05 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.40 Pain Relevance 0.50
The A1 allele is associated with a reduction in the density of D2 receptors at the striatum [8-10], although one study failed to replicate this finding [11].
allele Binding (associated) of in striatum
5) Confidence 0.05 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.73 Pain Relevance 0.43
However, associations between the DRD2 A1 allele and cannabis use disorders have not been published.
allele Binding (associations) of associated with cannabis
6) Confidence 0.05 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.45 Pain Relevance 0.62
Although the A1 allele was not associated with heroin dependence in the entire sample, the frequency of A1 allele was higher in male patients than in male controls (24.4% vs. 16.3%, P = 0.024, odds ratio = 1.65, 95% CI 1.07–2.57).
allele Binding (associated) of associated with addiction and opiate addiction
7) Confidence 0.04 Published 2007 Journal Behav Brain Funct Section Abstract Doc Link PMC1892032 Disease Relevance 0.25 Pain Relevance 0.35
However, in the particular case of opioid use disorders, associations with the A1 allele have been found in some studies [17,18], but not in others [19,20].
allele Binding (associations) of associated with opioid
8) Confidence 0.04 Published 2007 Journal Behav Brain Funct Section Body Doc Link PMC1892032 Disease Relevance 0.40 Pain Relevance 0.43
The majority of progeny were found to be mosaic with the presence of both the flox and deleted alleles, and there were no apparent phenotypic effects associated with the null allele.
allele Neg (no) Binding (associated) of
9) Confidence 0.01 Published 2001 Journal Mol. Genet. Metab. Section Abstract Doc Link 11708858 Disease Relevance 0.13 Pain Relevance 0.07
In addition, the -866 G allele is associated with an increased risk of chronic inflammatory diseases [16], and greater susceptibility to autoimmune diseases [10] and cardiovascular diseases [17-19].
allele Binding (associated) of associated with autoimmune disease, inflammation, cardiovascular disease and disease
10) Confidence 0.01 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.78 Pain Relevance 0.11
The G allele has also been associated with an increased risk of chronic inflammatory diseases [10,16] and cardiovascular diseases [17].
allele Binding (associated) of associated with inflammation, cardiovascular disease and disease
11) Confidence 0.01 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2987999 Disease Relevance 0.74 Pain Relevance 0.14
Clinically, the C allele has been associated with reduced fat mass and quadriceps strength [12].
allele Binding (associated) of in quadriceps
12) Confidence 0.01 Published 2010 Journal Curr Rheumatol Rep Section Body Doc Link PMC2902729 Disease Relevance 0.56 Pain Relevance 0.03
For example, highest expression of coding exons in the cerebellum, hippocampus, and striatum was associated with the B allele, whereas in prefrontal cortex and kidney, higher expression was generally associated with the D allele (Fig. 1B and Fig. 2).
D allele Binding (associated) of in prefrontal associated with hippocampus
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.44 Pain Relevance 0.08
The S allele has also been associated with diminished response to several SSRIs as compared with the L allele in multiple studies (Arias et al 2000; Pollock et al 2000; Zanardi et al 2000; Rausch, Johnson, et al 2002; Yu et al 2002; Arias et al 2003), with two exceptions in Asian populations (Kim et al 2000; Yoshida, Iko, et al 2002).
S allele Binding (associated) of associated with ssri
14) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2426818 Disease Relevance 0.24 Pain Relevance 0.40
However, the Met allele is associated with less pain and stress resiliency compared to the Val allele [40].
allele Binding (associated) of associated with stress and pain
15) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.56 Pain Relevance 0.59
The observed allele-haplotype interaction may have an effect on the regulatory role of the proteins and therefore on control of Ca levels.
allele Binding (interaction) of
16) Confidence 0.00 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.50 Pain Relevance 0
The same allele was significantly associated with both low body weight (A: 68.6 ± 9.0 kg vs.
allele Binding (associated) of in body associated with body weight
17) Confidence 0.00 Published 2010 Journal BMC Genet Section Body Doc Link PMC2975640 Disease Relevance 0.88 Pain Relevance 0

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