INT221472

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.05
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (SRI) transport (SRI) plasma membrane (SRI)
intracellular (SRI) cytoplasm (SRI)
SRI (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcium channel 2 85.20 High High
Dopamine 6 66.80 Quite High
Glutamate 2 58.84 Quite High
Hippocampus 2 33.76 Quite Low
Eae 4 5.00 Very Low Very Low Very Low
Enkephalin 2 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
dopamine receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 8 53.28 Quite High
Shock 2 35.32 Quite Low
Targeted Disruption 6 9.76 Low Low
Dislocations 3 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 2 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Leukemia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increase in functional MKP1 would reduce the sensitivity of the SCN to photic stimuli, and shut down the transcriptional mechanisms turned on by light.
Negative_regulation (reduce) of Regulation (sensitivity) of SCN
1) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0 Pain Relevance 0.03
However, given what is known about the role of Rrad in other systems, increased Rrad protein would also serve to downregulate the response of SCN cells to subsequent stimulation.
Negative_regulation (downregulate) of Regulation (response) of SCN
2) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.05 Pain Relevance 0.04
However, it is important to mention that these data do not define the contribution of the SCN to the regulation of the circadian rhythms in the RPE in vivo.
Neg (not) Negative_regulation (define) of Regulation (contribution) of SCN
3) Confidence 0.02 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3000237 Disease Relevance 0 Pain Relevance 0.03

General Comments

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