INT221477

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.27
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gadd45b) signal transduction (SRI) transport (SRI)
plasma membrane (SRI) intracellular (SRI) nucleus (Gadd45b)
Gadd45b (Mus musculus)
SRI (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 1 96.28 Very High Very High Very High
Glutamate 1 61.92 Quite High
Enkephalin 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Neuropeptide 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 1 97.84 Very High Very High Very High
Apoptosis 4 90.64 High High
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If Gadd45b acts to inhibit ERK activation in the SCN, then that would be consistent with the idea that some of these light-induced genes act to downregulate the sensitivity of the SCN to subsequent stimuli, and possibly contribute to the SCN's strong resistance to excitotoxicity [23].
Gadd45b Negative_regulation (inhibit) of SCN
1) Confidence 0.03 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2216081 Disease Relevance 0.27 Pain Relevance 0.08

General Comments

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