INT221513

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 3.26
Pain Relevance 2.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
dorsal 2
upper lip 1
trigeminal nerve 1
TRGV9 (Homo sapiens)
Pain Link Frequency Relevance Heat
fifth nerve 14 100.00 Very High Very High Very High
Pain 228 99.52 Very High Very High Very High
Neuropathic pain 16 91.84 High High
Trigeminal neuralgia 10 91.44 High High
imagery 22 87.12 High High
Lasting pain 6 76.44 Quite High
abdominal pain 16 71.92 Quite High
Spontaneous pain 26 70.20 Quite High
Shooting pain 8 66.80 Quite High
nud 14 60.00 Quite High
Disease Link Frequency Relevance Heat
Pain 274 99.52 Very High Very High Very High
Tics 204 98.88 Very High Very High Very High
Shock 22 95.28 Very High Very High Very High
Neuropathic Pain 32 91.84 High High
Headache 20 91.44 High High
Vomiting 24 79.48 Quite High
Abdominal Pain 16 71.92 Quite High
Muscular Spasm 2 63.44 Quite High
Dyspepsia 14 60.00 Quite High
Flatulence 20 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the influence of the V1 lesion on V2 and V3 activity, we identified retinotopically the V1-lesion projection zones (LPZ) in these areas (i.e. we selected the regions in dorsal V2, V3 that in pre-lesion retinotopy contain the same eccentricity information as the V1 area to be lesioned).
Spec (examine) Regulation (influence) of V2 in dorsal
1) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
In the second experiment (Figure 8C) we recorded from 7 cortical locations spanning the V2 LPZ border (5 inside, 2 outside the V2 LPZ), at two cortical depths per electrode (one superficial, one deep separated by ?
Regulation (spanning) of V2
2) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
Despite this however, both areas V2 and V3 show significant visual modulation following the chronic absence of retinotopically matched V1 input.
Regulation (modulation) of V2
3) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0.06 Pain Relevance 0
In any event, we can conclude that: 1) as expected, area V2, V3 activity is strongly dependent on area V1 input, yet 2) both areas V2 and V3 can be visually modulated even in the absence of retinotopically corresponding V1 input.
Regulation (modulated) of V2
4) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
While these results seem at odds with earlier studies of V2 and V3 responses following transient V1 inactivation [1], [3], [25], similar results have been obtained for area V5/MT [19], [22].
Regulation (responses) of V2
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
This suggests that: 1) the activity observed inside the area V2, V3 LPZs cannot arise as a result of input arising from dorsal V1 locations that lie outside the lesion (as might occur if the observed activity were due to a subpopulation of V2, V3 cells with large receptive fields reaching outside the lesioned area), and 2) the observed visual modulation in the LPZ of areas V2, V3 must be driven by retinotopically organized cortical or subcortical areas.
Spec (observed) Regulation (modulation) of V2 in dorsal
6) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
By contrast, results describing the function of visual areas V2 and V3 after long-standing V1 lesions are limited: 1) there are no electrophysiological studies addressing directly this issue in monkeys, and 2) neuroimaging studies of human “blindsight” patients have not produced definitive results: On the one hand, the fMRI study of hemianopic patients FS and GY by Goebel et al., appears to confirm results from primate electrophysiology suggesting that visually driven activity in areas V2, V3 is strictly dependent on V1 input [29].
Regulation (dependent) of V2
7) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
Of the three divisions of the trigeminal nerve, the second (V2) is most commonly affected.
Regulation (affected) of V2 in trigeminal nerve associated with fifth nerve
8) Confidence 0.14 Published 2007 Journal Mol Pain Section Body Doc Link PMC2217520 Disease Relevance 0.91 Pain Relevance 0.81
To investigate whether the retinotopic organization of areas V1, V2, V3 is changed (e.g. reorganized) after V1 lesioning, we compared visual eccentricity versus cortical distance plots (Materials and Methods) across these areas both in the lesioned and the intact hemispheres.
Regulation (changed) of V2
9) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677457 Disease Relevance 0 Pain Relevance 0
The pain was sharp, electrical in nature, and primarily affected the right V2 region, specifically the upper lip.
Regulation (affected) of V2 in upper lip associated with pain and fifth nerve
10) Confidence 0.07 Published 2007 Journal Mol Pain Section Body Doc Link PMC2217520 Disease Relevance 1.53 Pain Relevance 1.12
The statistical analysis showed no difference between test and control groups on wet stool weight at V2 or V3, or stool pH.
Neg (no) Regulation (difference) of V2
11) Confidence 0.05 Published 2009 Journal Nutr J Section Body Doc Link PMC2657159 Disease Relevance 0.40 Pain Relevance 0.17
However, at visit V2, the percentage of dry matter was statistically higher in the control than in the test group (ANOVA; p = 0.0013).
Regulation (control) of V2
12) Confidence 0.05 Published 2009 Journal Nutr J Section Body Doc Link PMC2657159 Disease Relevance 0.37 Pain Relevance 0.16

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