INT221539

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Context Info
Confidence 0.06
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.38
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cdh2) plasma membrane (Cdh2) protein complex (Cdh2)
Anatomy Link Frequency
cardiomyocytes 1
fibroblasts 1
Cdh2 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 37 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Root ganglion neuron 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
nociceptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 78 96.32 Very High Very High Very High
Ganglion Cysts 38 50.00 Quite Low
Arrhythmia Under Development 19 47.08 Quite Low
Embryonic Lethality 2 38.88 Quite Low
Hypertrophy 1 25.36 Quite Low
Shock 22 17.48 Low Low
Disease 7 5.00 Very Low Very Low Very Low
Heart Rate Under Development 5 5.00 Very Low Very Low Very Low
Arrhythmias 2 Under Development 4 5.00 Very Low Very Low Very Low
Heart Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the expression and localization of the adherens junction protein N-cadherin was unaffected (Fig. 7 B), the localization of the gap junction protein Connexin 43 (Cx43) was altered in KO cardiomyocytes 8 wk after induction (Fig. 7 C).
Neg (unaffected) Regulation (unaffected) of N-cadherin in cardiomyocytes associated with targeted disruption
1) Confidence 0.06 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2556793 Disease Relevance 0.38 Pain Relevance 0
Interestingly, Fer has also been implicated in regulation of N-cadherin interactions in fibroblasts [25,31] and cross-talk from N-cadherin to integrins in neural retina cells extending neurites on laminin [47]; and in neuronal cell polarity and neurite development [8].
Regulation (regulation) of N-cadherin in fibroblasts
2) Confidence 0.05 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0 Pain Relevance 0

General Comments

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