INT221542

Context Info Confidence 0.11 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.43 Pain Relevance 0.08

Anatomy Link Frequency growth cone 2 L1cam (Mus musculus)

Pain Link Frequency Relevance Heat dorsal root ganglion 37 95.96 withdrawal 1 5.00 Root ganglion neuron 1 5.00 nociceptor 1 5.00

Disease Link Frequency Relevance Heat Shock 22 97.68 Ganglion Cysts 38 95.96 Adhesions 1 90.76 Apoptosis 3 5.00 Targeted Disruption 3 5.00 Sprains And Strains 2 5.00 Death 1 5.00 Wallerian Degeneration 1 5.00 Urological Neuroanatomy 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CRMP2 is phosphorylated on threonine-555 by Rho kinase in response ephrinA5, and this blocked its tubulin binding and L1 endocytosis promoting properties, leading to growth cone collapse [43].

Negative_regulation (blocked) of L1 Binding (binding) of in growth cone associated with shock

1) Confidence 0.11 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.43 Pain Relevance 0.08

General Comments

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