INT221571

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Context Info
Confidence 0.55
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 0.56
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Fes) Golgi apparatus (Fes) plasma membrane (Fes)
cytoskeleton (Fes) kinase activity (Fes) cytoplasm (Fes)
Anatomy Link Frequency
upper 4
neuronal 1
brains 1
Fes (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 259 69.24 Quite High
withdrawal 7 5.00 Very Low Very Low Very Low
Root ganglion neuron 7 5.00 Very Low Very Low Very Low
nociceptor 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 14 86.20 High High
Ganglion Cysts 266 69.24 Quite High
Shock 154 60.32 Quite High
Adhesions 7 12.20 Low Low
Apoptosis 21 5.00 Very Low Very Low Very Low
Targeted Disruption 21 5.00 Very Low Very Low Very Low
Death 7 5.00 Very Low Very Low Very Low
Wallerian Degeneration 7 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since there are no obvious defects in the behaviour or activity of the Fer-, Fps- or compound Fer/Fps-mutant mice, we speculate that other kinases, perhaps members of the Src-subfamily like Fyn, might be able to compensate for loss of Fer/Fps kinases during development.
Negative_regulation (loss) of Fps
1) Confidence 0.55 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.06 Pain Relevance 0
In contrast, Fps and Fer activities were greatly diminished in adults, when neuronal connections have been largely consolidated.
Negative_regulation (diminished) of Fps in neuronal
2) Confidence 0.55 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.06 Pain Relevance 0
However, co-expression of PlexinA1 correlated with reduced autophosphorylation of both Fps and Fer (Fig. 4A, upper).
Negative_regulation (reduced) of Fps in upper
3) Confidence 0.40 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.13 Pain Relevance 0.06
A similar inhibition of both Fps and Fer autophosphorylation was observed in vitro when the purified GST-PlexinA1 protein was added as an exogenous substrate to anti-Fps/Fer immunoprecipitates from neonatal wt, fpsKR/KR, ferDR/DR or fpsKR/KR/ferDR/DR mouse brains (Fig. 4B, upper).
Negative_regulation (inhibition) of Fps in upper
4) Confidence 0.40 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.05 Pain Relevance 0.03
The apparent mass amounts of Fps and Fer in the anti-Fps/Fer immunoblots were also consistent with this interpretation (Fig. 3A, lower), and support the conclusion that there is more Fer than Fps in neonatal brains.
Negative_regulation (amounts) of Fps in brains
5) Confidence 0.40 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.07 Pain Relevance 0
Compared to wt, the Fps plus Fer kinase autophosphorylation was only slightly reduced in fps-/- lysates, substantially reduced in ferDR/DR, and abolished in fpsKR/KR/ferDR/DR lysates (Fig. 3A, upper).
Negative_regulation (abolished) of Fps in upper
6) Confidence 0.40 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.09 Pain Relevance 0
In vitro phosphorylation of exogenously added tubulin was comparable in wt and fps-/- lysates, substantially reduced in ferDR/DR, and abolished in fpsKR/KR/ferDR/DR lysates (Fig. 3B, upper).
Negative_regulation (abolished) of fpsKR in upper
7) Confidence 0.40 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.11 Pain Relevance 0.03

General Comments

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