INT2216

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Context Info
Confidence 0.77
First Reported 1979
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 92
Total Number 95
Disease Relevance 59.29
Pain Relevance 17.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (SELL) plasma membrane (SELL)
Anatomy Link Frequency
neutrophils 19
monocytes 12
leukocyte 11
T cells 9
upper limb 3
SELL (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 86 100.00 Very High Very High Very High
Enkephalin 66 100.00 Very High Very High Very High
ischemia 38 99.92 Very High Very High Very High
Substantia nigra 4 99.40 Very High Very High Very High
Fibrositis 21 99.14 Very High Very High Very High
Inflammation 1140 99.08 Very High Very High Very High
cytokine 613 99.04 Very High Very High Very High
Angina 57 98.88 Very High Very High Very High
metalloproteinase 18 98.52 Very High Very High Very High
Endogenous opioid 3 98.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 1274 100.00 Very High Very High Very High
Cancer 281 100.00 Very High Very High Very High
Necrosis 45 100.00 Very High Very High Very High
Coronary Artery Disease 69 99.92 Very High Very High Very High
Brain Injury 864 99.84 Very High Very High Very High
Nicotine Addiction 747 99.84 Very High Very High Very High
Disease 467 99.64 Very High Very High Very High
Inflammatory Bowel Disease 6 99.46 Very High Very High Very High
Diabetes Mellitus 17 99.44 Very High Very High Very High
Pheochromocytoma 4 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As compared to age and sex-matched healthy controls, FM patients showed a significantly decreased expression of CD62L (p < 0.01) and CD11b/CD18 (p < 0.05) on polymorphonuclear leukocytes.
Gene_expression (expression) of CD62L in polymorphonuclear leukocytes associated with fibrositis
1) Confidence 0.77 Published 2009 Journal Rheumatol. Int. Section Abstract Doc Link 19052753 Disease Relevance 0.78 Pain Relevance 0.39
Because stress is known to modulate adhesion molecule expression, we determined L: -selectin (CD62L) and beta(2)-integrin (CD11b/CD18) expression on the surface of polymorphonuclear leukocytes in 22 patients with FM.
Gene_expression (expression) of CD62L in polymorphonuclear leukocytes associated with stress, fibrositis and adhesions
2) Confidence 0.77 Published 2009 Journal Rheumatol. Int. Section Abstract Doc Link 19052753 Disease Relevance 0.82 Pain Relevance 0.37
Because stress is known to modulate adhesion molecule expression, we determined L: -selectin (CD62L) and beta(2)-integrin (CD11b/CD18) expression on the surface of polymorphonuclear leukocytes in 22 patients with FM.
Gene_expression (expression) of selectin in polymorphonuclear leukocytes associated with stress, fibrositis and adhesions
3) Confidence 0.77 Published 2009 Journal Rheumatol. Int. Section Abstract Doc Link 19052753 Disease Relevance 0.82 Pain Relevance 0.38
The expression of CD62L and CD11b on neutrophils after exposure to PSP/reg was analyzed by flow cytometry.
Spec (analyzed) Gene_expression (expression) of CD62L in PSP
4) Confidence 0.74 Published 2009 Journal Crit. Care Med. Section Body Doc Link 19325491 Disease Relevance 0.17 Pain Relevance 0
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) enhanced superoxide (O2-) release in human neutrophils stimulated by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) and inversely regulated the surface expression of cellular adhesion molecules, leukocyte adhesion molecule-1 (LAM-1) and CD11b/CD18 leukocyte integrin, on human neutrophils; that is, rhG-CSF downregulated the expression of LAM-1 and upregulated the expression of CD11b on neutrophils.
Gene_expression (expression) of leukocyte adhesion molecule-1 in neutrophils associated with adhesions
5) Confidence 0.74 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.20 Pain Relevance 0.39
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) enhanced superoxide (O2-) release in human neutrophils stimulated by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) and inversely regulated the surface expression of cellular adhesion molecules, leukocyte adhesion molecule-1 (LAM-1) and CD11b/CD18 leukocyte integrin, on human neutrophils; that is, rhG-CSF downregulated the expression of LAM-1 and upregulated the expression of CD11b on neutrophils.
Gene_expression (expression) of LAM-1 in neutrophils associated with adhesions
6) Confidence 0.74 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.20 Pain Relevance 0.44
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) enhanced superoxide (O2-) release in human neutrophils stimulated by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) and inversely regulated the surface expression of cellular adhesion molecules, leukocyte adhesion molecule-1 (LAM-1) and CD11b/CD18 leukocyte integrin, on human neutrophils; that is, rhG-CSF downregulated the expression of LAM-1 and upregulated the expression of CD11b on neutrophils.
Gene_expression (expression) of LAM-1 in leukocyte associated with adhesions
7) Confidence 0.74 Published 1994 Journal Exp. Hematol. Section Abstract Doc Link 7513653 Disease Relevance 0.19 Pain Relevance 0.48
Pre-incubation of enriched CD4+ T-cell subpopulations that express the homing receptor CD62L with nanomolar concentrations of the endogenous opioid peptide beta-endorphin leads to a more severe impairment of activation than that noted following pre-incubation with micromolar concentrations of cocaine alone.
Gene_expression (express) of CD62L in T-cell associated with endogenous opioid and cocaine
8) Confidence 0.69 Published 1994 Journal Immunopharmacology Section Abstract Doc Link 7852054 Disease Relevance 0.14 Pain Relevance 0.46
Our results are in accord with Seekamp et al [25] who showed a reduction, although not significant, in CD62L expression on neutrophils following elective knee surgery without the application of a tourniquet.
Gene_expression (expression) of CD62L in neutrophils
9) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.76 Pain Relevance 0.07
Measurement of cell surface expression of CD62L and CD11b
Gene_expression (expression) of CD62L
10) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.06 Pain Relevance 0.06
The present study was designed to ascertain whether tourniquet-applied upper limb orthopaedic surgery results in changes in the cell surface expression of the CD62L and CD11b adhesion molecules post surgery.
Gene_expression (expression) of CD62L in upper limb associated with adhesions
11) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.77 Pain Relevance 0.12
Changes in the cell surface expression of CD62L and CD11b following tourniquet-applied upper limb orthopaedic surgery is associated with cell activation.
Gene_expression (expression) of CD62L in upper limb
12) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.61 Pain Relevance 0.07
During this investigation there was evidence of decreased CD62L expression at the cell surface of neutrophils probably due to shedding of this adhesion molecule.
Gene_expression (expression) of CD62L in neutrophils associated with adhesions
13) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.86 Pain Relevance 0.11
However, another explanation of the decrease observed in the CD62L cell surface expression of neutrophils could be that when endothelial cells become activated, the subset of neutrophils with the highest expression of CD62L may tend to roll and adhere which would leave the cells with lesser CD62L-expression in the circulation available for blood sampling.
Gene_expression (expression) of CD62L in neutrophils
14) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.87 Pain Relevance 0.13
Thus increased expression of CD11b and decreased expression of CD62L by neutrophils and monocytes may play a central role as the mechanism by which leukocyte adhesion and consequently activation occurs following surgery [2], [21], [26].
Gene_expression (expression) of CD62L in monocytes associated with adhesions
15) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2911384 Disease Relevance 0.79 Pain Relevance 0.08
Furthermore, the current results showing reduced surface expression of CD62L in HSD-treated patients, accompanied by corresponding increases in sL-selectin and better patient outcome, are in accordance with our previous findings in shock patients [14], and supports the theory that sL-selectin shedding represents an endogenous regulatory mechanism to limit leukocyte-mediated injury [79].


Gene_expression (expression) of CD62L in leukocyte associated with injury and shock
16) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.97 Pain Relevance 0.14
A majority (90-100%) of PMNs and monocytes from patients and controls were found to constitutively express CD62L and CD11b, with no significant temporal or intergroup differences in the proportion of cells bearing these receptors.
Neg (no) Gene_expression (express) of CD62L in monocytes
17) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.47 Pain Relevance 0
After conventional crystalloid resuscitation, we found that relative to healthy controls, brain-injured patients exhibit extensive leukocyte mobilization, with significantly enhanced PMN and monocyte surface expression of L-selectin (CD62L) and ?
Gene_expression (expression) of CD62L in brain
18) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.20 Pain Relevance 0.06
Expression of CD62L by PMNs and monocytes were elevated in the NS group across all sample times relative to control, whereas HSD treatment significantly down-regulated CD62L expression at all time points.
Gene_expression (expression) of CD62L in monocytes
19) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.21 Pain Relevance 0
Results of this study show that leukocytes from TBI patients resuscitated with NS display rapid induction of constitutively expressed CD62L and activation of CD11b with translocation to the cell membrane from intracellular secretory granules [31].
Gene_expression (expressed) of CD62L in leukocytes associated with brain injury
20) Confidence 0.68 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 1.00 Pain Relevance 0.14

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