INT22160

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Context Info
Confidence 0.38
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 4.94
Pain Relevance 5.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) extracellular space (Car2) lyase activity (Car2)
cytoplasm (Car2)
Anatomy Link Frequency
sensory neurons 2
neurons 2
astrocytes 2
nucleus 2
heart 2
Car2 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 71 100.00 Very High Very High Very High
tetrodotoxin 7 99.84 Very High Very High Very High
nMDA receptor 85 99.28 Very High Very High Very High
Paracetamol 22 99.04 Very High Very High Very High
Kinase C 21 98.44 Very High Very High Very High
cytokine 66 97.40 Very High Very High Very High
antagonist 32 97.12 Very High Very High Very High
cINOD 112 96.48 Very High Very High Very High
Morphine 78 96.00 Very High Very High Very High
sodium channel 1 95.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 77 100.00 Very High Very High Very High
Coronary Artery Disease 1 99.76 Very High Very High Very High
Targeted Disruption 17 99.64 Very High Very High Very High
Sprains And Strains 5 98.92 Very High Very High Very High
Myocardial Infarction 2 98.80 Very High Very High Very High
Death 126 98.56 Very High Very High Very High
Nervous System Injury 21 98.04 Very High Very High Very High
Hypertrophy 1 98.04 Very High Very High Very High
INFLAMMATION 40 94.52 High High
Neuropathic Pain 57 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dithiothreitol prevented both further cell injury and an increase in the cytosolic [Ca2+].
Negative_regulation (prevented) of Positive_regulation (increase) of Ca2 associated with injury
1) Confidence 0.38 Published 1993 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8513431 Disease Relevance 0.65 Pain Relevance 0.62
Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen-induced liver injury.
Negative_regulation (loss) of Positive_regulation (accumulation) of Ca2 in nucleus associated with paracetamol and injury
2) Confidence 0.38 Published 1990 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 2256122 Disease Relevance 0.39 Pain Relevance 0.48
However, other investigators have reported that the inactivation of Ca2+-ATPase is closely related with ischemic heart disease, heart failure, and hypertrophy of cardiac muscle; thus, as the intracellular Ca2+ concentration increases, the concentration of ryanodine receptor decreases, and in some cases, down regulation has been found to be associated with the decreased expression of its mRNA.23,24
Negative_regulation (related) of Positive_regulation (inactivation) of Ca2 in heart associated with hypertrophy, coronary artery disease and myocardial infarction
3) Confidence 0.35 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687630 Disease Relevance 0.35 Pain Relevance 0
Pretreatment with chlorpromazine prevented increases in nuclear Ca2+ and DNA fragmentation and nearly abolished biochemical evidence of toxic cell death.
Negative_regulation (prevented) of Positive_regulation (increases) of Ca2 associated with death
4) Confidence 0.28 Published 1993 Journal FASEB J. Section Abstract Doc Link 8462787 Disease Relevance 1.20 Pain Relevance 0.51
The elevation of NO and Ca2+ signals were abolished by tetrodotoxin.
Negative_regulation (abolished) of Positive_regulation (elevation) of Ca2 associated with tetrodotoxin
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659787 Disease Relevance 0.37 Pain Relevance 0.46
However, the ACh (10-3 M, in the presence of 10-4 M GTP)-induced Ca2+ sensitizing effect was inhibited by treatment with C3 in both the sensitized control and OA-challenged groups (Fig. 3).
Negative_regulation (inhibited) of Positive_regulation (induced) of Ca2
6) Confidence 0.20 Published 2005 Journal Respir Res Section Body Doc Link PMC545934 Disease Relevance 0 Pain Relevance 0
Salicylate and R-flurbiprofen also prevented the [Ca2+]mit rise induced by A?
Negative_regulation (prevented) of Positive_regulation (induced) of Ca2
7) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.07 Pain Relevance 0.24
We find that salicylate, indomethacin and R-flurbiprofen inhibit the mitochondrial Ca2+ overload induced by either A?
Negative_regulation (inhibit) of Positive_regulation (induced) of Ca2
8) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.16 Pain Relevance 0.33
Specifically, salicylate at 100 µM and R-flurbiprofen at 1 µM inhibited by 77±4% and 85±3%, respectively (mean±SEM) the [Ca2+]mit increase induced by A?
Negative_regulation (inhibited) of Positive_regulation (increase) of Ca2
9) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2447871 Disease Relevance 0.06 Pain Relevance 0.30
However, voltage-gated Ca2+ currents are also diminished after nerve injury [48] and this has been proposed to lead to increased excitability in injured sensory neurons via reduced activation of Ca2+ activated K+ currents.
Negative_regulation (reduced) of Positive_regulation (activation) of Ca2 in sensory neurons associated with nervous system injury
10) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.72 Pain Relevance 0.28
Despite increases in [Ca2+]i (induced by treating astrocytes with 5 mM Ca2+), inhibiting the activation of NF-?
Negative_regulation (inhibiting) of Positive_regulation (increases) of Ca2 in astrocytes
11) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2605563 Disease Relevance 0 Pain Relevance 0.91
The increased [Ca2+]i accompanying deoxygenation was completely inhibited by the selective blocker of stretch-activated ion channels, GsMTx-4 (1 µM, P<10?
Negative_regulation (inhibited) of Positive_regulation (increased) of Ca2
12) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806905 Disease Relevance 0.10 Pain Relevance 0
Dimebon inhibits glutamate-induced Ca2+ increase in YAC128 MSN
Negative_regulation (inhibits) of Positive_regulation (increase) of Ca2 associated with glutamate
13) Confidence 0.10 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2577671 Disease Relevance 0.24 Pain Relevance 0.19
Thus, in agreement with our previous findings [12,14,15], the increase in Ca2+ was significantly higher in YAC128 MSN than in WT MSN.
Negative_regulation (higher) of Positive_regulation (increase) of Ca2
14) Confidence 0.10 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2577671 Disease Relevance 0 Pain Relevance 0.33
NM inhibits TRPM7-induced increases in intracellular Ca2+ in cultured hippocampal and cortical neurons
Negative_regulation (inhibits) of Positive_regulation (increases) of Ca2 in neurons
15) Confidence 0.09 Published 2010 Journal Mol Brain Section Body Doc Link PMC3022637 Disease Relevance 0 Pain Relevance 0.04
In addition, the hippocampal slices of Ng knockout mice displayed a reduced activation of Ca2+/CaM-dependent kinase II (CaMKII) and PKC isozymes, as well as PKA.
Negative_regulation (reduced) of Positive_regulation (activation) of Ca2 associated with targeted disruption and kinase c
16) Confidence 0.06 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1865092 Disease Relevance 0.56 Pain Relevance 0.38
In 9 of 15 cells recorded, intracellular solution containing 40 mM BAPTA was used to fully suppress accumulation of intracellular Ca2+ associated with NMDA receptor activation.
Negative_regulation (suppress) of Positive_regulation (accumulation) of Ca2 associated with nmda receptor
17) Confidence 0.06 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.34
However, flow-induced Ca2+ signals were virtually abolished in the same cells after the induction of TRPV4 siRNA expression by tetracycline (Fig. 3, C, E, G, and H).
Negative_regulation (abolished) of Positive_regulation (induced) of Ca2
18) Confidence 0.05 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2500130 Disease Relevance 0.07 Pain Relevance 0.03

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