INT22161

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Context Info
Confidence 0.52
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 3.96
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) cytoplasm (Oxt)
Anatomy Link Frequency
brain 6
PVN 2
uterine 2
Oxt (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 15 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
cytokine 24 99.98 Very High Very High Very High
antidepressant 5 99.56 Very High Very High Very High
Dismenorea 10 98.52 Very High Very High Very High
Inflammation 15 97.88 Very High Very High Very High
fluoxetine 5 91.60 High High
analgesia 15 91.40 High High
anesthesia 3 81.84 Quite High
amygdala 2 81.32 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 23 99.60 Very High Very High Very High
Appetite Loss 5 99.52 Very High Very High Very High
Anxiety Disorder 58 98.64 Very High Very High Very High
Dysmenorrhea 10 98.52 Very High Very High Very High
Asthma 37 97.88 Very High Very High Very High
INFLAMMATION 16 97.88 Very High Very High Very High
Stress 55 90.68 High High
Reprotox - General 1 3 90.68 High High
Necrosis 3 74.24 Quite High
Cancer 5 73.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate the role of this opioid peptide in the control of oxytocin (OT) synthesis and sodium appetite regulation we used mice with gene dosage-dependent variations in brain beta-endorphin content, expressing either 100%, 50%, or 0% of normal beta-endorphin content.
Spec (investigate) Regulation (role) of Gene_expression (synthesis) of OT in brain associated with appetite loss and opioid
1) Confidence 0.52 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.26 Pain Relevance 0.28
The effect of a potent oxytocin antagonist, produced in our laboratories, on spontaneous uterine contractions in the pregnant baboon was examined.
Spec (examined) Regulation (effect) of Gene_expression (produced) of oxytocin in uterine associated with antagonist and dismenorea
2) Confidence 0.44 Published 1990 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 2256498 Disease Relevance 0.26 Pain Relevance 0.43
Both control HT and KO mice showed higher OT mRNA expression levels than control WT group and these levels did not change after induced sodium intake.
Neg (not) Regulation (change) of Gene_expression (expression) of OT associated with targeted disruption
3) Confidence 0.44 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.29 Pain Relevance 0.05
To investigate the role of this opioid peptide in the control of oxytocin (OT) synthesis and sodium appetite regulation we used mice with gene dosage-dependent variations in brain beta-endorphin content, expressing either 100%, 50%, or 0% of normal beta-endorphin content.
Regulation (control) of Gene_expression (synthesis) of oxytocin in brain associated with appetite loss and opioid
4) Confidence 0.44 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.26 Pain Relevance 0.27
The data suggests that the Avpr1b is required to drive the HPA axis response to acute antidepressant treatment and provides further evidence of a sexual dichotomy in the regulation of PVN Avp/Oxt gene expression following antidepressant administration.
Regulation (regulation) of Gene_expression (expression) of Oxt in PVN associated with antidepressant
5) Confidence 0.42 Published 2008 Journal Psychoneuroendocrinology Section Abstract Doc Link 18243568 Disease Relevance 0.40 Pain Relevance 0.81
Our findings imply that changes in oxytocin expression may contribute to the changes in anxiety level of CaMKIV-/- mice.
Regulation (changes) of Gene_expression (expression) of oxytocin associated with anxiety disorder
6) Confidence 0.39 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 1.22 Pain Relevance 0.21
[Changes in the 13,14-dihydro-15-ketoprostaglandin F2alpha and oxytocin level in the 1st trimester following beta-sympathomimetic and intracervical prostaglandin E2 gel administration].
Regulation ([Changes) of Gene_expression (level) of oxytocin
7) Confidence 0.34 Published 1988 Journal Zentralbl Gynakol Section Title Doc Link 3213310 Disease Relevance 0.09 Pain Relevance 0.08
This conclusion would support the hypothesis that OT inhibits sodium intake and provides new evidence about beta-endorphin modulation of OT synthesis and sodium appetite.
Regulation (modulation) of Gene_expression (synthesis) of OT
8) Confidence 0.23 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.08 Pain Relevance 0
To investigate the role of this opioid peptide in the control of oxytocin (OT) synthesis and sodium appetite regulation we used mice with gene dosage-dependent variations in brain beta-endorphin content, expressing either 100%, 50%, or 0% of normal beta-endorphin content.
Regulation (control) of Gene_expression (synthesis) of OT in brain associated with appetite loss and opioid
9) Confidence 0.23 Published 2003 Journal Neuroscience Section Abstract Doc Link 14580937 Disease Relevance 0.26 Pain Relevance 0.27
CONCLUSION: Taken together, we show that cytokines modulate the expression of functional oxytocin receptors in HASMCs suggesting a potential role for inflammation-induced changes in oxytocin receptor signaling in the regulation of airway hyper-responsiveness in asthma.


Regulation (modulate) of Gene_expression (expression) of oxytocin
10) Confidence 0.22 Published 2010 Journal Respir. Res. Section Body Doc Link 20670427 Disease Relevance 0 Pain Relevance 0
Taken together, we show that cytokines modulate the expression of functional oxytocin receptors in HASMCs suggesting a potential role for inflammation-induced changes in oxytocin receptor signaling in the regulation of airway hyper-responsiveness in asthma.



Regulation (modulate) of Gene_expression (expression) of oxytocin associated with asthma, inflammation and cytokine
11) Confidence 0.21 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2922094 Disease Relevance 0.56 Pain Relevance 0.10
The correlation between Oxytocin level and
Regulation (correlation) of Gene_expression (level) of Oxytocin
12) Confidence 0.14 Published 2009 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2778188 Disease Relevance 0.28 Pain Relevance 0.08

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