INT221630

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 1.02
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Fes) signal transduction (Plxna1) Golgi apparatus (Fes)
intracellular (Plxna1) plasma membrane (Fes) cytoskeleton (Fes)
Fes (Mus musculus)
Plxna1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 222 96.08 Very High Very High Very High
nociceptor 6 89.12 High High
withdrawal 6 5.00 Very Low Very Low Very Low
Root ganglion neuron 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 228 96.08 Very High Very High Very High
Shock 132 88.88 High High
Sprains And Strains 12 15.04 Low Low
Apoptosis 18 5.00 Very Low Very Low Very Low
Targeted Disruption 18 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Wallerian Degeneration 6 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results argue that PlexinA1 can interact in some way with Fps and Fer kinases and modify their kinase activities, but not necessarily by acting as a substrate.
Fps Binding (interact) of PlexinA1
1) Confidence 0.01 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0 Pain Relevance 0
A "pull-down" assay using the GST-PlexinA1 cytoplasmic domain fusion was also performed to further test for possible association between PlexinA1 and Fps or Fer.
Fps Binding (association) of PlexinA1
2) Confidence 0.01 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0 Pain Relevance 0
PlexinA1 association with and phosphorylation by Fps or Fer were first examined in co-transfection studies.
Fps Binding (association) of PlexinA1
3) Confidence 0.01 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.18 Pain Relevance 0.09
The study from Mitsui and colleagues used transfection studies to suggest a functional relationship between Fps and PlexinA1 [20], and the biochemical studies we report here also relied upon over-expression in transfected cells to suggest regulatory interactions between Fps and Fer with PlexinA1 and CRMP2.
Fps Binding (interactions) of PlexinA1
4) Confidence 0.01 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.27 Pain Relevance 0.20
Using transfection studies, they went on to show that Fps could interact with and phosphorylated the Sema3A receptor component PlexinA1; and that this stimulated the phosphorylation of CRMP/CRAM proteins.
Fps Binding (interact) of PlexinA1
5) Confidence 0.01 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.39 Pain Relevance 0.12
PlexinA1 association with and phosphorylation by Fps or Fer were first examined in co-transfection studies.
Fps Binding (association) of PlexinA1
6) Confidence 0.01 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.18 Pain Relevance 0.09

General Comments

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