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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.77
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) cell morphogenesis (Bcl2) endoplasmic reticulum (Bcl2)
intracellular (Bcl2) cytoplasm (Bcl2) cell proliferation (Bcl2)
Anatomy Link Frequency
cleavage 1
Bcl2 (Mus musculus)
Pain Link Frequency Relevance Heat
methotrexate 2 98.28 Very High Very High Very High
cytokine 19 96.20 Very High Very High Very High
Inflammation 25 95.80 Very High Very High Very High
Spinal cord 81 89.44 High High
Inflammatory mediators 1 82.68 Quite High
Crohn's disease 1 67.04 Quite High
ischemia 20 50.00 Quite Low
fibrosis 1 27.84 Quite Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 97 99.56 Very High Very High Very High
INFLAMMATION 31 95.80 Very High Very High Very High
Metastasis 4 94.00 High High
Head Trauma 1 93.60 High High
Stomach Cancer 2 93.44 High High
Brain Injury 1 91.40 High High
Cancer 64 91.28 High High
Injury 73 90.68 High High
Myelitis 1 89.96 High High
Spinal Cord Injury 122 87.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the parameters investigated, low histologic grade, positive ER, positive PR, positive bcl-2 and low level of Ki-67 were associated with prolonged RFS in univariate analysis.
Protein_catabolism (grade) of bcl-2
1) Confidence 0.24 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2217558 Disease Relevance 0.15 Pain Relevance 0.03
Since a BH4-domain containing peptide is generated by caspase cleavage of BCL2, it is likely that BH4-peptides are also released extracellularly [58].
Protein_catabolism (cleavage) of BCL2 in cleavage
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816997 Disease Relevance 0.39 Pain Relevance 0.04
B expression, (6) p-ERK1/2 and p38 expression and (7) apoptosis (TUNEL staining, FAS ligand, Bax and Bcl-2 expression).
Protein_catabolism (ligand) of Bcl-2 associated with apoptosis
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935363 Disease Relevance 1.48 Pain Relevance 0.33
For example, REG4 expression seems to be responsible for cell resistance to anticancer drugs such as 5-fluouracil and methotrexate [15], [20], it promotes AKT phosphorylation and over-expression of the antiapoptotic proteins Bcl-2, Bcl-xL and survivin [21], [22], it activates the EGF receptor/Akt/AP1 signaling pathway [21] and its expression correlates with enhanced peritoneal metastasis in gastric carcinomas [22], [23].
Protein_catabolism (proteins) of Bcl-2 associated with methotrexate, stomach cancer and metastasis
4) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760775 Disease Relevance 0.75 Pain Relevance 0.08

General Comments

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