INT2217

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Context Info
Confidence 0.69
First Reported 1979
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 7.66
Pain Relevance 6.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ins1) extracellular region (Ins1) carbohydrate metabolic process (Ins1)
cytoplasm (Ins1)
Anatomy Link Frequency
plasma 14
nerve 4
blood 2
fat 2
muscle 2
Ins1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 29 99.98 Very High Very High Very High
Morphine 20 99.58 Very High Very High Very High
Bile 61 98.92 Very High Very High Very High
adenocard 2 98.64 Very High Very High Very High
opioid receptor 4 97.00 Very High Very High Very High
allodynia 4 96.12 Very High Very High Very High
tolerance 6 95.52 Very High Very High Very High
Intracerebroventricular 3 93.84 High High
ketamine 1 91.20 High High
narcan 6 90.80 High High
Disease Link Frequency Relevance Heat
Insulin Resistance 42 100.00 Very High Very High Very High
Hyperinsulinism 21 100.00 Very High Very High Very High
Stress 18 100.00 Very High Very High Very High
Cancer 2 99.64 Very High Very High Very High
Fistula 19 99.08 Very High Very High Very High
Hypertension 8 98.24 Very High Very High Very High
Hypothermia 8 97.12 Very High Very High Very High
Muscular Atrophy 5 96.88 Very High Very High Very High
Body Weight 10 96.84 Very High Very High Very High
Hypoglycemia 12 96.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The infusion of glucose raised the fetal blood glucose concentration to that of the mother and induced a rapid increase of plasma insulin levels on day 19.5 of gestation.
Positive_regulation (induced) of Positive_regulation (increase) of insulin in plasma
1) Confidence 0.69 Published 1979 Journal Biol. Neonate Section Abstract Doc Link 383163 Disease Relevance 0.41 Pain Relevance 0.08
Increased insulin circulating levels induced by canatoxin in rats.
Positive_regulation (Increased) of Positive_regulation (induced) of insulin associated with hyperinsulinism
2) Confidence 0.69 Published 1993 Journal Toxicon Section Title Doc Link 8266345 Disease Relevance 0.51 Pain Relevance 0.11
Dynamics of glucose-induced plasma insulin increase in the rat fetus at different stages of gestation.
Positive_regulation (increase) of Positive_regulation (increase) of insulin in plasma
3) Confidence 0.50 Published 1979 Journal Biol. Neonate Section Title Doc Link 383163 Disease Relevance 0.43 Pain Relevance 0.07
Nosedrops containing both a small amount of alkylglycoside (0.03-0.50%) and insulin (2 U regular porcine) caused a rapid decrease in blood D-glucose levels and a concomitant increase in serum immunoreactive insulin levels.
Positive_regulation (caused) of Positive_regulation (increase) of insulin in blood
4) Confidence 0.47 Published 1994 Journal Endocrinology Section Abstract Doc Link 7988421 Disease Relevance 0 Pain Relevance 0.14
Pentobarbital anesthesia caused an elevation in basal glucose and insulin levels in Wistar rats at 9 and 16 weeks of age and in SH rats at 9 weeks.
Positive_regulation (caused) of Positive_regulation (elevation) of insulin associated with anesthesia and hypertension
5) Confidence 0.47 Published 2002 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 12450062 Disease Relevance 1.04 Pain Relevance 0.37
Barbiturate treatment alone led to large increases of corticosterone and smaller but significant increases of glucose, insulin, and glucagon.
Positive_regulation (increases) of Positive_regulation (increases) of insulin
6) Confidence 0.46 Published 1982 Journal Am. J. Physiol. Section Abstract Doc Link 7039355 Disease Relevance 0.14 Pain Relevance 0.16
In addition, intravenous amino acids administration during anesthesia induces an increase in the plasma insulin level.
Positive_regulation (induces) of Positive_regulation (increase) of insulin in plasma associated with anesthesia
7) Confidence 0.46 Published 2010 Journal J. Nutr. Sci. Vitaminol. Section Abstract Doc Link 20495293 Disease Relevance 0.63 Pain Relevance 0.48
Physiologic elevation of insulin levels induces a significant increase in muscle adenosine triphosphate (ATP) synthesis rate in normal individuals, indicative of an appropriate acceleration in mitochondrial activity.
Positive_regulation (induces) of Positive_regulation (elevation) of insulin in muscle associated with adenocard
8) Confidence 0.46 Published 2008 Journal Metab. Clin. Exp. Section Abstract Doc Link 18940398 Disease Relevance 0.06 Pain Relevance 0.09
Increased insulin circulating levels induced by canatoxin in rats.
Positive_regulation (induced) of Positive_regulation (Increased) of insulin associated with hyperinsulinism
9) Confidence 0.46 Published 1993 Journal Toxicon Section Title Doc Link 8266345 Disease Relevance 0.51 Pain Relevance 0.11
The increase of plasma insulin and blood glucose-lowering action induced by racecadotril were reduced by pretreatment with atropine and enhanced by physotigmine.
Positive_regulation (enhanced) of Positive_regulation (increase) of insulin in plasma
10) Confidence 0.45 Published 2010 Journal Horm. Metab. Res. Section Abstract Doc Link 20143290 Disease Relevance 0.07 Pain Relevance 0.16
The increase of plasma insulin and blood glucose-lowering action induced by racecadotril were reduced by pretreatment with atropine and enhanced by physotigmine.
Positive_regulation (induced) of Positive_regulation (increase) of insulin in plasma
11) Confidence 0.45 Published 2010 Journal Horm. Metab. Res. Section Abstract Doc Link 20143290 Disease Relevance 0.06 Pain Relevance 0.16
Both the monomethyl and dimethyl esters of succinic acid, administered intravenously to fasted and anesthetized rats, caused a rapid increase in plasma insulin.
Positive_regulation (caused) of Positive_regulation (increase) of insulin in plasma
12) Confidence 0.40 Published 1994 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7979832 Disease Relevance 0.07 Pain Relevance 0
Data suggest that the oxidative stress contributes to the induction and up-regulation of B(1)R in the model of insulin resistance induced by glucose feeding.
Positive_regulation (induction) of Positive_regulation (induced) of insulin associated with stress and insulin resistance
13) Confidence 0.39 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17988733 Disease Relevance 1.03 Pain Relevance 0.46
Thiopental anesthesia induced a rapid increase in plasma insulin that was more pronounced in the animals treated with BR (116%, P <0.05).
Positive_regulation (induced) of Positive_regulation (increase) of insulin in plasma associated with anesthesia
14) Confidence 0.36 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 12832843 Disease Relevance 0 Pain Relevance 0.43
The regulation of clonal rat insulinoma (RINm5F) cell proliferation and hormone accumulation was investigated with the aim of identifying putative compounds capable of inducing differentiation, i.e. decreased growth and increased insulin accumulation, by the tumor cells.
Spec (investigated) Positive_regulation (increased) of Spec (investigated) Positive_regulation (accumulation) of insulin associated with hypoglycemia, cancer and hyperinsulinism
15) Confidence 0.32 Published 1995 Journal Ups. J. Med. Sci. Section Abstract Doc Link 8808183 Disease Relevance 0.37 Pain Relevance 0.03
The dose dependent increase in fasting insulin was further increased when the same dose of Dex was administered to high-fat fed [HF-HD and HF-LD] rats [Fig. 1].
Positive_regulation (increased) of Positive_regulation (increase) of insulin in fat
16) Confidence 0.31 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.22 Pain Relevance 0
Combined infusion of insulin and glucose, which resulted in increased serum insulin levels with euglycemia, significantly augmented adrenergic nerve-mediated pressor responses and attenuated CGRPergic nerve-mediated depressor responses.
Positive_regulation (resulted) of Positive_regulation (increased) of insulin in nerve
17) Confidence 0.30 Published 2008 Journal Hypertens. Res. Section Abstract Doc Link 18712059 Disease Relevance 0.68 Pain Relevance 0.42
Combined infusion of insulin and glucose, which resulted in increased serum insulin levels with euglycemic, significantly augmented adrenergic nerve-mediated pressor responses and attenuated CGRPergic nerve-mediated depressor responses.
Positive_regulation (resulted) of Positive_regulation (increased) of insulin in nerve
18) Confidence 0.28 Published 2008 Journal Yakugaku Zasshi Section Abstract Doc Link 18311062 Disease Relevance 0.53 Pain Relevance 0.38
In contrast, the gastric acid secretion induced by the vagal mediated secretagogues, insulin, 2-deoxy-D-glucose (2-D-G) and RWIS, was markedly increased by IM pretreatment.
Positive_regulation (increased) of Positive_regulation (induced) of insulin associated with stress
19) Confidence 0.25 Published 1985 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3886988 Disease Relevance 0.65 Pain Relevance 0.45
Finally, as was the case for insulin induced stimulation of ornithine decarboxylase activity, i.c.v. injection of morphine markedly diminished insulin induced stimulation of hepatic ornithine decarboxylase mRNA accumulation.
Positive_regulation (induced) of Positive_regulation (accumulation) of insulin associated with morphine
20) Confidence 0.12 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 1.06

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