INT22170

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Context Info
Confidence 0.38
First Reported 1986
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 23
Total Number 23
Disease Relevance 3.54
Pain Relevance 9.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
APT 4
tail 2
muscle 1
tongue 1
jaw 1
D1Jor3 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 11 99.92 Very High Very High Very High
Raphe magnus 6 99.88 Very High Very High Very High
Clonidine 13 99.82 Very High Very High Very High
Calcium channel 1 99.80 Very High Very High Very High
Central grey 12 99.72 Very High Very High Very High
Acupuncture 25 99.56 Very High Very High Very High
intrathecal 1 99.12 Very High Very High Very High
Somatosensory cortex 15 98.98 Very High Very High Very High
qutenza 30 98.24 Very High Very High Very High
lidocaine 5 97.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 12 99.72 Very High Very High Very High
Li-fraumeni Syndrome 2 99.56 Very High Very High Very High
Bruxism 12 98.24 Very High Very High Very High
Stress 9 96.08 Very High Very High Very High
Nociception 6 96.00 Very High Very High Very High
Depression 13 95.52 Very High Very High Very High
Temporomandibular Joint Syndrome 3 85.48 High High
INFLAMMATION 3 78.80 Quite High
Pain 2 66.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intravenously administered afloqualone, a centrally acting muscle relaxant, inhibited both JOR and its parallels promptly and dose-dependently.
Negative_regulation (inhibited) of JOR in muscle
1) Confidence 0.38 Published 1990 Journal Dtsch Zahnarztl Z Section Abstract Doc Link 2257798 Disease Relevance 0 Pain Relevance 0.09
Increasing doses of MDMA (1-29440 micro g kg(-1)) induced an incomplete inhibition of JOR and 50% inhibition (ED(50)) at 2550 micro g kg(-1); maximal inhibition was 88%.
Negative_regulation (inhibition) of JOR
2) Confidence 0.35 Published 2004 Journal Eur. J. Oral Sci. Section Abstract Doc Link 15056109 Disease Relevance 0.15 Pain Relevance 0.13
This study shows that the intravenous administration of MDMA reduces the JOR while repeated doses of the drug enhance the inhibitory noradrenergic mechanisms which regulate the reflex.
Negative_regulation (reduces) of JOR
3) Confidence 0.30 Published 2004 Journal Eur. J. Oral Sci. Section Abstract Doc Link 15056109 Disease Relevance 0.12 Pain Relevance 0.14
The repeated treatment with MDMA led to an enhancement of the inhibition of JOR induced by the alpha(2)-agonist, clonidine (ED(50) was reduced by 77%), indicating an increased sensitivity of the alpha(2)-adrenoceptors.
Negative_regulation (inhibition) of JOR associated with agonist and clonidine
4) Confidence 0.30 Published 2004 Journal Eur. J. Oral Sci. Section Abstract Doc Link 15056109 Disease Relevance 0.13 Pain Relevance 0.15
The results also allow speculation that a reduction of JOR may underlie the occurrence of episodes of bruxism in MDMA users.
Negative_regulation (reduction) of JOR associated with bruxism
5) Confidence 0.30 Published 2004 Journal Eur. J. Oral Sci. Section Abstract Doc Link 15056109 Disease Relevance 0.15 Pain Relevance 0.13
On the saline-treated side, the JOR was gradually inhibited by manual acupuncture stimulation of the ipsilateral hindpaw (80 s), and the effect continued after the cessation of the stimulus.
Negative_regulation (inhibited) of JOR associated with acupuncture
6) Confidence 0.30 Published 1996 Journal Brain Res. Section Abstract Doc Link 8973815 Disease Relevance 0 Pain Relevance 0.61
These results suggest that the capsaicin-sensitive thin afferent fibers (A delta and C afferent fibers) mediated by receptors such as polymodal receptors are activated by manual acupuncture stimulation and that they participate in the peripheral processes that of inhibition of the JOR by diffuse noxious inhibitory controls.
Negative_regulation (inhibition) of JOR associated with qutenza and acupuncture
7) Confidence 0.30 Published 1996 Journal Brain Res. Section Abstract Doc Link 8973815 Disease Relevance 0 Pain Relevance 0.43
Immersion of the hindpaw in hot water (53 degrees C, 40 s) induced a rapid and potent inhibition of the JOR on the saline-treated side, but not on the capsaicin-treated side.
Negative_regulation (inhibition) of JOR associated with qutenza
8) Confidence 0.30 Published 1996 Journal Brain Res. Section Abstract Doc Link 8973815 Disease Relevance 0 Pain Relevance 0.73
The inhibition of the JOR was elicited by manual acupuncture stimulation of various segmental areas such as the nose, auricle, forepaw, abdomen, hindleg and hindpaw.
Negative_regulation (inhibition) of JOR in nose associated with acupuncture
9) Confidence 0.30 Published 1996 Journal Brain Res. Section Abstract Doc Link 8973815 Disease Relevance 0 Pain Relevance 0.65
The MO injection induced a long-lasting suppression of the amplitude of both ipsilaterally and contralaterally evoked JOR, although the latency and duration of the JOR were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of JOR
10) Confidence 0.30 Published 2005 Journal Brain Res. Bull. Section Abstract Doc Link 16144653 Disease Relevance 0.31 Pain Relevance 0.36
The inhibition of the JOR was elicited by manual acupuncture stimulation of various segmental areas such as the nose, auricle, forepaw, abdomen, hindleg and hindpaw.
Negative_regulation (inhibition) of JOR in auricle associated with acupuncture
11) Confidence 0.10 Published 1996 Journal Brain Res. Section Abstract Doc Link 8973815 Disease Relevance 0 Pain Relevance 0.65
Electric low-frequency stimulation (LFS, 1 Hz) of the tongue suppressed the JOR integral by 43% for at least 1 h.
Negative_regulation (suppressed) of JOR in tongue associated with li-fraumeni syndrome
12) Confidence 0.08 Published 2005 Journal Brain Res. Section Abstract Doc Link 15713281 Disease Relevance 0.99 Pain Relevance 0.75
However, the dose-response curve for clonidine-induced inhibition of the JOR was clearly shifted to the right in rats exposed to repeated tail pinch (ED50 was increased by 152%, P < 0.0001) when compared with the unstressed control group, without affecting the slope of the inhibitory function and the estimated maximum effect for the agonist.
Negative_regulation (inhibition) of JOR in tail associated with agonist and clonidine
13) Confidence 0.02 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9694532 Disease Relevance 0.15 Pain Relevance 0.35
Single tail pinch did not significantly modify the ability of the agonist to inhibit the JOR, although there was a tendency to decrease the basal amplitude of the reflex (a 40% reduction) immediately after exposure to the single stressor.
Negative_regulation (inhibit) of JOR in tail associated with agonist
14) Confidence 0.02 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9694532 Disease Relevance 0.14 Pain Relevance 0.34
We assessed in the rat the effects of either single or repeated tail pinch on clonidine-induced inhibition of the jaw-opening reflex (JOR) via activation of postsynaptic central alpha2-adrenoceptors.
Negative_regulation (inhibition) of JOR in jaw associated with clonidine
15) Confidence 0.02 Published 1998 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9694532 Disease Relevance 0.10 Pain Relevance 0.26
These findings collectively suggest that the cortically-induced inhibition of the JOR is at least partly mediated by a relay in the APT.
Negative_regulation (inhibition) of JOR in APT
16) Confidence 0.01 Published 1990 Journal Brain Res. Section Abstract Doc Link 2357560 Disease Relevance 0 Pain Relevance 0.16
A similar time course of inhibition of the JOR was noted with APT conditioning stimulation.
Negative_regulation (inhibition) of JOR in APT
17) Confidence 0.01 Published 1990 Journal Brain Res. Section Abstract Doc Link 2357560 Disease Relevance 0 Pain Relevance 0.26
Local unilateral injection of 2% lidocaine (0.3-0.6 microliter) into APT could partially and reversibly reduce the ipsilateral cortically evoked inhibition of the JOR.
Negative_regulation (inhibition) of JOR in APT associated with lidocaine
18) Confidence 0.01 Published 1990 Journal Brain Res. Section Abstract Doc Link 2357560 Disease Relevance 0 Pain Relevance 0.24
Ibotenic acid (5 micrograms, 0.5 microliter)-induced unilateral lesions of APT and its adjoining structures also greatly reduced the ipsilateral cortically induced inhibition of the JOR.
Negative_regulation (inhibition) of JOR in APT
19) Confidence 0.01 Published 1990 Journal Brain Res. Section Abstract Doc Link 2357560 Disease Relevance 0 Pain Relevance 0.22
Conditioning stimulation of the ipsilateral or contralateral somatosensory cortex in chloralose-urethane anaesthetized rats induced inhibition of the JOR elicited by test stimulation of the maxillary skin or tooth pulp, at conditioning-test intervals between 30 and 200 ms.
Negative_regulation (inhibition) of JOR in skin associated with somatosensory cortex
20) Confidence 0.01 Published 1990 Journal Brain Res. Section Abstract Doc Link 2357560 Disease Relevance 0 Pain Relevance 0.26

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