INT221703

Context Info Confidence 0.26 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.03

endosome (KCNK1) plasma membrane (KCNK1) cytoplasm (KCNK1)

KCNK1 (Homo sapiens)

Pain Link Frequency Relevance Heat Bioavailability 32 53.68 imagery 1 42.28 corticosteroid 3 5.00 lidocaine 3 5.00 cINOD 2 5.00 transdermal 2 5.00 Inflammation 2 5.00 fibrosis 1 5.00 withdrawal 1 5.00 Nicotine 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 5 5.00 Blister 5 5.00 Increased Venous Pressure Under Development 5 5.00 Injury 4 5.00 Fungal Infection 4 5.00 Skin Diseases 2 5.00 Fibrosis 1 5.00 Dermatological Disease 1 5.00 Alopecia 1 5.00 Toxicity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These physicochemical parameters are relevant to DPK in that they report, respectively, on the extent and the rate of drug uptake into the SC: the partition coefficient (K) reflects the relative affinity of the drug for the SC compared to the applied formulation and is related to the extent of absorption, therefore; the ratio D/L2 has units of (time)?

Positive_regulation (related) of Gene_expression (relevant) of DPK

1) Confidence 0.26 Published 2007 Journal Pharm Res Section Body Doc Link PMC2217624 Disease Relevance 0 Pain Relevance 0.03

General Comments

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