INT221781

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Context Info
Confidence 0.28
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.14
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Camk4, Mef2d) cell differentiation (Mef2d) signal transduction (Camk4)
nucleocytoplasmic transport (Camk4) enzyme binding (Mef2d) DNA binding (Mef2d)
Anatomy Link Frequency
neuronal 1
Camk4 (Mus musculus)
Mef2d (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 1 91.08 High High
Nucleus accumbens 47 80.20 Quite High
long-term potentiation 1 6.24 Low Low
Eae 8 5.00 Very Low Very Low Very Low
amygdala 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
narcan 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 34 73.88 Quite High
Targeted Disruption 7 20.96 Low Low
Sprains And Strains 1 11.20 Low Low
Congenital Anomalies 3 8.64 Low Low
Post-traumatic Stress Disorder 10 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CaMKIV activates several transcription factors such as ATF-1, MEF2D and NF-kappaB [4-6], and is a key regulator of neuronal gene expression that stimulates transcription through the phosphorylation of the cAMP response element binding protein (CREB) and activation of the CREB co-activator, CREB binding protein (CBP) [2,3,7].
CaMKIV Positive_regulation (activates) of MEF2D in neuronal
1) Confidence 0.28 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2219998 Disease Relevance 0.14 Pain Relevance 0.22

General Comments

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