INT221815

Context Info Confidence 0.15 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.50 Pain Relevance 0.05

lipid metabolic process (PPARA, PTEN) lipid binding (PPARA, PTEN) nucleus (PPARA, PTEN) nucleoplasm (PPARA) small molecule metabolic process (PPARA) enzyme binding (PTEN)

PPARA (Homo sapiens) PTEN (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 3 99.76 agonist 8 5.00 Inflammation 5 5.00 chemokine 5 5.00 cytokine 4 5.00 cINOD 1 5.00 Inflammatory response 1 5.00 Bile 1 5.00 metalloproteinase 1 5.00

Disease Link Frequency Relevance Heat Non-small-cell Lung Cancer 19 94.40 Apoptosis 14 77.80 Cancer 46 72.20 Lung Cancer 29 53.52 Death 2 32.00 INFLAMMATION 7 5.00 Metastasis 3 5.00 Obesity 3 5.00 Adenocarcinoma 3 5.00 Hepatocellular Cancer 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

and PTEN were blocked by the selective PPAR-?

PPAR Negative_regulation (blocked) of PTEN

1) Confidence 0.15 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.50 Pain Relevance 0.05

General Comments

This test has worked.