INT221830

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Context Info
Confidence 0.18
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.15
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND1) nucleoplasm (CCND1) nucleus (CCND1)
intracellular (CCND1) enzyme binding (CCND1) cell division (CCND1)
Anatomy Link Frequency
embryos 2
CCND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 3 53.12 Quite High
Central nervous system 1 47.20 Quite Low
Nicotine 5 21.88 Low Low
agonist 14 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
chemokine 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoma 1 100.00 Very High Very High Very High
Non-small-cell Lung Cancer 41 98.88 Very High Very High Very High
Lung Cancer 61 94.48 High High
Cancer 86 92.60 High High
Apoptosis 24 90.88 High High
Death 6 86.08 High High
Adhesions 3 67.84 Quite High
Myopia 22 58.12 Quite High
Adenocarcinoma 6 39.72 Quite Low
Hyperopia 9 32.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
reduction in cyclin D1 mRNA expression [40].
Negative_regulation (reduction) of Transcription (expression) of cyclin D1
1) Confidence 0.18 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.95 Pain Relevance 0
with a reduction in cyclin D1 mRNA expression [84].
Negative_regulation (reduction) of Transcription (expression) of cyclin D1
2) Confidence 0.06 Published 2007 Journal PPAR Research Section Body Doc Link PMC2220082 Disease Relevance 0.97 Pain Relevance 0
In these embryos, the mRNA expression of v-jun sarcoma virus 17 oncogene homolog, FOS, 3-phosphoinositide dependent protein kinase-1 and Cyclin D1 was found to be downregulated by roughly twofold [54].
Negative_regulation (downregulated) of Transcription (expression) of Cyclin D1 in embryos associated with sarcoma
3) Confidence 0.03 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2528026 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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