INT221859

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Context Info
Confidence 0.14
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 7
Disease Relevance 2.21
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Jup) cytoplasm (Jup) cytosol (Jup)
structural molecule activity (Jup) cell adhesion (Jup) nucleus (Jup)
Anatomy Link Frequency
tail 1
plaque 1
keratinocyte 1
Jup (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 78 5.00 Very Low Very Low Very Low
metalloproteinase 36 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
imagery 19 5.00 Very Low Very Low Very Low
corticosteroid 13 5.00 Very Low Very Low Very Low
addiction 12 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 307 99.66 Very High Very High Very High
Bullous Skin Disease 1824 96.56 Very High Very High Very High
Disease 148 82.00 Quite High
Acantholysis 390 62.88 Quite High
Autoimmune Disease 24 55.60 Quite High
Arrhythmogenic Right Ventricular Dysplasia 23 50.00 Quite Low
Embryonic Lethality 18 48.48 Quite Low
Sudden Death 22 47.68 Quite Low
Cardiomyopathy 5 38.72 Quite Low
Blister 72 13.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cytoplasmic domains are largely embedded in the outer dense plaque (ODP) where they are associated with plakoglobin and plakophilin.
plakoglobin Binding (associated) of in plaque
1) Confidence 0.14 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0 Pain Relevance 0
Because the same binding site is required for interaction of plakoglobin to ?
plakoglobin Binding (interaction) of
2) Confidence 0.14 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.24 Pain Relevance 0
Binding sites for both plakoglobin and plakophilin are situated in the N-terminal domain of desmoplakin.
plakoglobin Binding (Binding) of
3) Confidence 0.12 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2222049 Disease Relevance 0.28 Pain Relevance 0
Moreover, plakoglobin phosphorylation was shown to be required for EGFR-induced loss of cell adhesion and to regulate binding of plakoglobin to desmoplakin (Miravet et al. 2003; Yin et al. 2005).
plakoglobin Binding (binding) of associated with adhesions
4) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.48 Pain Relevance 0
Pemphigus IgG were found to include a plethora of more than 20 different autoantibodies against keratinocyte antigens such as antibodies against Dsg 1, Dsg 4, Dsc 1-3, desmoplakin, plakoglobin and E-cadherin and several other proteins not associated with cell junctions (Amagai et al. 2006; Evangelista et al. 2008; Kljuic et al. 2003; Korman et al. 1989; Nguyen et al. 2000c).
plakoglobin Binding (associated) of in keratinocyte associated with bullous skin disease
5) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.74 Pain Relevance 0
It is believed that the cytoplasmic tail of Dsgs and Dscs interact with plakoglobin which in turn binds to desmoplakin (Fig. 1).
plakoglobin Binding (interact) of in tail
6) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.20 Pain Relevance 0
Plakoglobin binds to the cytoplasmic cadherin-typical sequence of Dsgs and Dscs via its first three armadillo repeat domains (Chitaev et al. 1998).
Plakoglobin Binding (binds) of
7) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.27 Pain Relevance 0

General Comments

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