INT221860

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 6.82
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Jup) cytoplasm (Jup) cytosol (Jup)
structural molecule activity (Jup) cell adhesion (Jup) nucleus (Jup)
Anatomy Link Frequency
keratinocyte 2
ventricle 1
interventricular septum 1
plaque 1
Jup (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 196 65.84 Quite High
Kinase C 65 57.36 Quite High
addiction 10 44.32 Quite Low
agonist 25 20.48 Low Low
fibrosis 17 12.56 Low Low
metalloproteinase 30 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 1619 99.18 Very High Very High Very High
Disease 185 98.96 Very High Very High Very High
Apoptosis 98 98.16 Very High Very High Very High
Acantholysis 335 97.88 Very High Very High Very High
Targeted Disruption 49 96.68 Very High Very High Very High
Adhesions 283 94.68 High High
Blister 100 90.36 High High
Darier's Disease 5 77.36 Quite High
Sudden Death 31 63.60 Quite High
Arrhythmogenic Right Ventricular Dysplasia 44 57.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A deletion in plakoglobin was first found in Naxos disease in 2000 [26], followed by mutation of demoplakin in 2002 [27], plakophilin-2 in 2004 [28], desmoglein-2 in 2006 [29] and desmocollin-2 also in 2006 [30] (Table 3).
Negative_regulation (deletion) of plakoglobin associated with disease
1) Confidence 0.15 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2222049 Disease Relevance 0.49 Pain Relevance 0
This can be concluded from experiments which showed that autoantibody binding as well as keratinocyte separation started between desmosomes (Sato et al. 2000; Takahashi et al. 1985) and that non-junctional Dsg 3 and plakoglobin were depleted first before changes in the desmosomal fractions were present (Aoyama and Kitajima 1999; Williamson et al. 2006; Yamamoto et al. 2007a).
Negative_regulation (depleted) of plakoglobin in keratinocyte
2) Confidence 0.13 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.69 Pain Relevance 0.03
Therefore, keratinocytes deficient for either plakoglobin or desmoplakin display reduced numbers of desmosomes, disturbed plaque formation and reduced anchorage of cytokeratin filaments (Bierkamp et al. 1999; Vasioukhin et al. 2001).
Negative_regulation (deficient) of plakoglobin in plaque
3) Confidence 0.13 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.16 Pain Relevance 0
These mechanisms may, amongst others, involve expression of genes different from c-Myc, which is suggested by the fact that plakoglobin deficiency resulted in protection of keratinocytes from apoptosis, possibly via overexpression of the anti-apoptotic molecule Bcl-XL (Dusek et al. 2007a).
Negative_regulation (deficiency) of plakoglobin in keratinocytes associated with apoptosis
4) Confidence 0.13 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.34 Pain Relevance 0
After 24 h, Dsg 3 but not Dsg 2, plakoglobin or desmoplakin was also depleted from the cytoskeletal fractions leading to reduced total cellular Dsg 3 levels (Calkins et al. 2006; Yamamoto et al. 2007a).
Negative_regulation (depleted) of plakoglobin
5) Confidence 0.13 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.25 Pain Relevance 0
In addition, plakoglobin regulates the turn over of desmosomal components because the protein levels of desmogleins as well as of plakoglobin and desmoplakin were decreased in plakoglobin-deficient cells (Yin et al. 2005).
Negative_regulation (decreased) of plakoglobin
6) Confidence 0.13 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.57 Pain Relevance 0
Results from another group implicated depletion of the cellular plakoglobin pool leading to increased expression of c-Myc to be critical for PV pathogenesis [17, 19].
Negative_regulation (depletion) of plakoglobin associated with bullous skin disease
7) Confidence 0.12 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 1.55 Pain Relevance 0
It has been reported that pemphigus antibodies trigger a rapid turnover and reduction of the nuclear pool of plakoglobin, thereby abolishing plakoglobin's role as a transcriptional repressor of the proto-oncogene c-Myc [24].
Negative_regulation (reduction) of plakoglobin associated with bullous skin disease
8) Confidence 0.10 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2902105 Disease Relevance 1.01 Pain Relevance 0
Importantly, the plakoglobin level was reduced not only in the right ventricle, but also in the left ventricle and interventricular septum.
Negative_regulation (reduced) of plakoglobin in ventricle
9) Confidence 0.02 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933459 Disease Relevance 0.27 Pain Relevance 0.08
They showed an excellent diagnostic value of reduced plakoglobin levels in the biopsy sample, with a sensitivity of 91%, a specificity of 82%, a positive predictive value of 83%, and a negative predictive value of 90%.
Negative_regulation (reduced) of plakoglobin
10) Confidence 0.02 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933459 Disease Relevance 0.23 Pain Relevance 0.06
Importantly, the plakoglobin level was reduced not only in the right ventricle, but also in the left ventricle and interventricular septum.
Negative_regulation (reduced) of plakoglobin in interventricular septum
11) Confidence 0.01 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2933459 Disease Relevance 0.27 Pain Relevance 0.08

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