INT221865

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 4.56
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (RYR2) transmembrane transport (RYR2)
Anatomy Link Frequency
reticulum 2
RYR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 51.32 Quite High
sodium channel 14 5.00 Very Low Very Low Very Low
imagery 13 5.00 Very Low Very Low Very Low
Action potential 8 5.00 Very Low Very Low Very Low
potassium channel 6 5.00 Very Low Very Low Very Low
beta blocker 6 5.00 Very Low Very Low Very Low
Calcium channel 6 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ventricular Tachycardia 28 98.92 Very High Very High Very High
Disease 74 94.80 High High
Sudden Death 34 91.96 High High
Heart Rate Under Development 50 90.72 High High
Cardiomyopathy 31 90.40 High High
Malignant Neoplastic Disease 8 89.52 High High
Muscle Disease 10 88.72 High High
Congenital Anomalies 14 80.36 Quite High
Arrhythmogenic Right Ventricular Dysplasia 21 79.00 Quite High
Dilated Cardiomyopathy 6 76.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tiso et al suggested that ARVD2 associated mutations increase RYR2 mediated calcium release to the cytoplasm where as CPVT associated mutations do not significantly affect cytosolic calcium levels.
Positive_regulation (increase) of Localization (release) of RYR2 associated with ventricular tachycardia
1) Confidence 0.15 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 1.79 Pain Relevance 0.03
Tiso et al suggested that ARVD2 associated mutations increase RYR2 mediated calcium release to the cytoplasm where as CPVT associated mutations do not significantly affect cytosolic calcium levels.
Positive_regulation (mediated) of Localization (release) of RYR2 associated with ventricular tachycardia
2) Confidence 0.15 Published 2008 Journal Indian Pacing and Electrophysiology Journal Section Body Doc Link PMC2363724 Disease Relevance 1.78 Pain Relevance 0.03
One is the gene encoding for the cardiac ryanodine receptor 2, which is located in the smooth sarcoplasmic reticulum and mediates calcium release for electroanatomical coupling (ARVD2 with polymorphic ventricular arrhythmias) [32].
Positive_regulation (mediates) of Localization (release) of ARVD2 in reticulum
3) Confidence 0.15 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2222049 Disease Relevance 0.99 Pain Relevance 0

General Comments

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