INT22187

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 5.26
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1D) signal transducer activity (HTR1D)
Anatomy Link Frequency
atrium 1
nerve 1
brain 1
meninges 1
circle of Willis 1
HTR1D (Homo sapiens)
Pain Link Frequency Relevance Heat
noradrenaline 3 99.98 Very High Very High Very High
Pain 46 99.64 Very High Very High Very High
Sumatriptan 172 99.48 Very High Very High Very High
Migraine 88 99.44 Very High Very High Very High
agonist 25 97.68 Very High Very High Very High
Triptan 57 97.16 Very High Very High Very High
Neurotransmitter 1 96.96 Very High Very High Very High
Inflammatory response 1 95.36 Very High Very High Very High
antagonist 5 95.16 Very High Very High Very High
headache 32 93.64 High High
Disease Link Frequency Relevance Heat
Pain 47 99.64 Very High Very High Very High
Migraine Disorders 6 99.44 Very High Very High Very High
Headache 107 97.36 Very High Very High Very High
Increased Venous Pressure Under Development 12 96.92 Very High Very High Very High
INFLAMMATION 21 95.36 Very High Very High Very High
Cluster Headache 11 92.28 High High
Obesity 2 83.28 Quite High
Syndrome 4 76.48 Quite High
Neurogenic Inflammation 8 74.72 Quite High
Neurological Disease 1 72.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These were shown to be the 5-HT1D receptors, which are densely localized in humans on tissues known to be involved in the pathogenesis of migraine, such as the carotid artery, the circle of Willis, and meninges.
Localization (localized) of 5-HT1D in meninges associated with migraine
1) Confidence 0.78 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846149 Disease Relevance 1.75 Pain Relevance 1.48
These receptors are present in certain intracranial blood vessels. 5-HT1D receptors are also located on nerve terminals where they act to inhibit the release of 5-HT and other neurotransmitters.
Localization (located) of 5-HT1D in nerve associated with neurotransmitter
2) Confidence 0.73 Published 1990 Journal Neurol Clin Section Abstract Doc Link 2259314 Disease Relevance 0.71 Pain Relevance 0.50
Inhibition of noradrenaline release via presynaptic 5-HT1D alpha receptors in human atrium.
Localization (release) of 5-HT1D in atrium associated with noradrenaline
3) Confidence 0.73 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.43
Evidence for presynaptic location of inhibitory 5-HT1D beta-like autoreceptors in the guinea-pig brain cortex.
Localization (location) of 5-HT1D in brain
4) Confidence 0.73 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 8692282 Disease Relevance 0 Pain Relevance 0.25
Neural 5-HT1D and/or 5-HT1F receptors localized pre-junctionally on trigeminovascular afferents appear to mediate the triptan-induced inhibition of the neurogenic inflammatory response, with possible additional sites of action for brain penetrant 5-HT1 receptor agonists in inhibiting the transmission of pain centrally.
Localization (localized) of 5-HT1D in Neural associated with pain, inflammatory response, agonist and triptan
5) Confidence 0.73 Published 1999 Journal Can J Neurol Sci Section Abstract Doc Link 10563226 Disease Relevance 0.95 Pain Relevance 1.15
We have taken advantage of a new selective 5-HT1D receptor agonist 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate, Sumatriptan, to evaluate the role of 5-HT1D receptors on GH secretion.
Localization (secretion) of 5-HT1D associated with sumatriptan and agonist
6) Confidence 0.68 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7775648 Disease Relevance 0.08 Pain Relevance 0.66
These were shown to be the 5-HT1D receptors, which are densely localized in humans on tissues known to be involved in the pathogenesis of migraine, such as the carotid artery, the circle of Willis, and meninges.
Localization (localized) of 5-HT1D in circle of Willis associated with migraine
7) Confidence 0.26 Published 2010 Journal Drug design, development and therapy Section Body Doc Link PMC2846149 Disease Relevance 1.75 Pain Relevance 1.48

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