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Context Info
Confidence 0.66
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.61
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F12) extracellular space (F12) extracellular region (F12)
plasma membrane (F12)
Anatomy Link Frequency
plasma 1
F12 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 23 93.52 High High
TRP channel 5 91.60 High High
antagonist 36 91.04 High High
agonist 20 86.32 High High
qutenza 2 69.44 Quite High
Analgesic 5 55.48 Quite High
Inflammation 8 51.16 Quite High
Eae 6 41.16 Quite Low
Pain 22 35.08 Quite Low
allodynia 1 33.80 Quite Low
Disease Link Frequency Relevance Heat
Disease 40 99.34 Very High Very High Very High
Cardiovascular Disease 70 97.76 Very High Very High Very High
Hereditary Angioedema 197 97.48 Very High Very High Very High
Stroke 33 91.36 High High
Pressure And Volume Under Development 107 90.96 High High
Coronary Artery Disease 48 90.68 High High
INFLAMMATION 5 51.16 Quite High
Stress 1 48.76 Quite Low
Injury 2 48.04 Quite Low
Neuropathic Pain 2 40.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The location of these mutations is the same locus, 5q33-qter of the Hageman factor or coagulation FXII gene (Online Mendelian Inheritance in Man # 610619).
Gene_expression (qter) of Hageman factor
1) Confidence 0.66 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2919521 Disease Relevance 0.54 Pain Relevance 0
On the day of the assay, culture media was removed and cells were incubated with assay buffer (F12 containing 30 mM HEPES for TRPA1, TRPM8, TRPV1 and TRPV3; F12 containing 30 mM HEPES, 1 mM CaCl2, and 0.3% BSA for TRPV4) containing 15 ?
Gene_expression (containing) of F12
2) Confidence 0.65 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222611 Disease Relevance 0 Pain Relevance 0.39
Several allelic variants conferred disease risk for men and women jointly, including rs1801020 in coagulation factor XII (HR?
Gene_expression (including) of coagulation factor XII associated with disease
3) Confidence 0.61 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2574036 Disease Relevance 1.49 Pain Relevance 0
Cugno and colleagues have speculated that the significant increases in prothrombin fragment F1+2 in the coagulation pathway may involve increased plasma levels of factor XII, an initiator of the contact pathway that is activated during HAE attacks [18].
Gene_expression (levels) of factor XII in plasma associated with hereditary angioedema
4) Confidence 0.03 Published 2008 Journal Clin Mol Allergy Section Body Doc Link PMC2374835 Disease Relevance 0.58 Pain Relevance 0.11

General Comments

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