INT221938

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tceb1)
TRPA1 (Homo sapiens)
Tceb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 81 99.96 Very High Very High Very High
agonist 60 96.88 Very High Very High Very High
Potency 9 75.36 Quite High
imagery 6 55.16 Quite High
TRP channel 15 45.72 Quite Low
Analgesic 15 34.24 Quite Low
Pain 48 27.68 Quite Low
Eae 18 24.52 Low Low
Cold hyperalgesia 15 23.40 Low Low
Inflammation 15 19.52 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 29.60 Quite Low
Pain 48 27.68 Quite Low
Hyperalgesia 15 23.40 Low Low
Nervous System Injury 6 20.20 Low Low
INFLAMMATION 6 19.52 Low Low
Neurogenic Inflammation 9 5.00 Very Low Very Low Very Low
Neuropathic Pain 6 5.00 Very Low Very Low Very Low
Inflammatory Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We further confirmed the antagonism of TCEB compounds at human TRPA1 by electrophysiology studies that demonstrated similar IC50 values, indicating TCEB compounds are the most potent TRPA1 antagonists reported to date.
TRPA1 Binding (compounds) of TCEB associated with antagonist
1) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222611 Disease Relevance 0 Pain Relevance 0.30
We further confirmed the antagonism of TCEB compounds at human TRPA1 by electrophysiology studies that demonstrated similar IC50 values, indicating TCEB compounds are the most potent TRPA1 antagonists reported to date.
TRPA1 Binding (compounds) of TCEB associated with antagonist
2) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222611 Disease Relevance 0 Pain Relevance 0.27
All four TCEB compounds that we report here inhibited both AITC and noxious cold activation of human TRPA1 but exhibited differential pharmacology at rat TRPA1.
TRPA1 Binding (compounds) of TCEB
3) Confidence 0.02 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222611 Disease Relevance 0 Pain Relevance 0.14

General Comments

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