INT221955

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.93
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ELAVL1, CDK5R1) cytosol (ELAVL1, CDK5R1) nucleus (ELAVL1, CDK5R1)
nucleoplasm (ELAVL1) embryo development (CDK5R1) cell proliferation (CDK5R1)
Anatomy Link Frequency
neuronal 2
SH-SY5Y 1
neuron 1
ELAVL1 (Homo sapiens)
CDK5R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 44 86.24 High High
Neurotransmitter 4 24.68 Low Low
cerebral cortex 4 5.00 Very Low Very Low Very Low
Neuritis 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 36 99.16 Very High Very High Very High
Nervous System Malformation 36 85.60 High High
Neurodegenerative Disease 44 74.00 Quite High
Cognitive Disorder 16 72.24 Quite High
Intellectual Impairment 20 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Syndrome 12 5.00 Very Low Very Low Very Low
Breast Cancer 8 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 8 5.00 Very Low Very Low Very Low
Neuritis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested the binding of the nELAV RBPs to the CDK5R1 transcript by immunoprecipitating endogenous mRNA-protein (mRNP) complexes from SH-SY5Y cells with the pan-neuronal ELAV antibody.
nELAV Binding (binding) of CDK5R1 in SH-SY5Y
1) Confidence 0.01 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0 Pain Relevance 0
We have also observed a stabilizing effect of the 3' end region containing a canonical ARE in two neuroblastoma cell lines and have obtained evidence of binding of the neuronal-specific ELAV (nELAV) proteins to CDK5R1 mRNA.
nELAV Binding (binding) of CDK5R1 mRNA in neuronal associated with neuroblastoma
2) Confidence 0.01 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.39 Pain Relevance 0.07
We have also observed a stabilizing effect of the 3' end region containing a canonical ARE in two neuroblastoma cell lines and have obtained evidence of binding of the neuronal-specific ELAV (nELAV) proteins to CDK5R1 mRNA.
ELAV Binding (binding) of CDK5R1 mRNA in neuronal associated with neuroblastoma
3) Confidence 0.01 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.39 Pain Relevance 0.07
Our results on interaction of the nELAV factors with CDK5R1 messenger in a neuronal cell line support the hypothesis of a neuron-specific post-transcriptional regulation of CDK5R1 expression.
nELAV Binding (interaction) of CDK5R1 in neuron
4) Confidence 0.01 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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