INT221963

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.58
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (ELAVL1, CDK5R1) cytosol (ELAVL1, CDK5R1) nucleus (ELAVL1, CDK5R1)
nucleoplasm (ELAVL1) embryo development (CDK5R1) cell proliferation (CDK5R1)
Anatomy Link Frequency
neurons 2
ELAVL1 (Homo sapiens)
CDK5R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 11 65.12 Quite High
cerebral cortex 1 42.92 Quite Low
Neuritis 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 11 97.88 Very High Very High Very High
Cognitive Disorder 4 97.00 Very High Very High Very High
Disease 4 84.36 Quite High
Neurological Disease 1 66.00 Quite High
Syndrome 3 49.16 Quite Low
Intellectual Impairment 5 47.00 Quite Low
Congenital Anomalies 1 41.16 Quite Low
Attention Deficit Hyperactivity Disorder 2 25.52 Quite Low
Nervous System Malformation 9 18.64 Low Low
Neuroblastoma 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our study evidences for the first time the involvement of 3'-UTR in the modulation of CDK5R1 expression by the presence of both destabilizing and stabilizing cis-regulatory elements in 3'-UTR, also supporting the hypothesis that CDK5R1 gene expression is controlled in neurons by nELAV-mediated mechanisms, with potential implications in neurodegenerative and cognitive disorders.
nELAV Regulation (controlled) of Gene_expression (expression) of CDK5R1 in neurons associated with cognitive disorder and neurodegenerative disease
1) Confidence 0.01 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.58 Pain Relevance 0.03

General Comments

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