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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.87
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (CDK5) cytoplasm (CDK5) cell proliferation (CDK5)
cytosol (CDK5) nucleocytoplasmic transport (CDK5) cell death (CDK5)
Anatomy Link Frequency
neuronal 1
CDK5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 22 85.76 High High
cerebral cortex 2 81.60 Quite High
Neuritis 2 52.12 Quite High
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 6 96.80 Very High Very High Very High
Aging 2 96.76 Very High Very High Very High
Apoptosis 2 96.28 Very High Very High Very High
Neurodegenerative Disease 22 95.60 Very High Very High Very High
Intellectual Impairment 10 95.00 High High
Attention Deficit Hyperactivity Disorder 4 93.12 High High
Nervous System Malformation 18 86.24 High High
Congenital Anomalies 2 84.96 Quite High
Motor Neuron Diseases 2 77.28 Quite High
Disease 8 75.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has recently been demonstrated in mouse that p35 protein level is a rate-limiting factor for the up-regulation of Cdk5 activity [59].
Regulation (regulation) of Cdk5
1) Confidence 0.42 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.59 Pain Relevance 0.08
More recently the CDK5/p35 complex has also been reported to regulate several activities such as exocytosis, gene transcription, tissue regeneration, senescence, apoptosis and hormone regulation also in extra-neuronal cells [20].
Regulation (regulate) of CDK5 in neuronal associated with aging and apoptosis
2) Confidence 0.31 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 1.28 Pain Relevance 0.08

General Comments

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