INT221973

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Context Info
Confidence 0.57
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.26
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (CDK5) cytoplasm (CDK5) cell proliferation (CDK5)
cytosol (CDK5) nucleocytoplasmic transport (CDK5) cell death (CDK5)
Anatomy Link Frequency
neurons 2
eosinophil 1
CDK5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 23 79.32 Quite High
Inflammation 30 72.44 Quite High
Neuritis 2 64.88 Quite High
tetrodotoxin 1 21.84 Low Low
Ziconotide 1 10.76 Low Low
agonist 10 5.00 Very Low Very Low Very Low
complementary and alternative medicine 10 5.00 Very Low Very Low Very Low
cytokine 7 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 10 99.92 Very High Very High Very High
Neurodegenerative Disease 24 98.80 Very High Very High Very High
Disease 26 96.84 Very High Very High Very High
Convulsion 2 92.84 High High
Cancer 19 91.12 High High
Neuroblastoma 21 86.28 High High
Adhesions 5 84.64 Quite High
Nervous System Malformation 19 79.80 Quite High
INFLAMMATION 31 72.44 Quite High
Prostate Cancer 1 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deregulation of CDK5/p25 has been associated with neurodegenerative diseases including Alzheimer’s disease, therefore it was included in the panel of kinases tested.
Negative_regulation (Deregulation) of CDK5 associated with disease and neurodegenerative disease
1) Confidence 0.57 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630805 Disease Relevance 1.00 Pain Relevance 0.03
In mice lacking Cdk5 or p35, abnormal formation of cortical layers occurs: a loss of the Cdk5 pathway appears to affect later migrating neurons as the cortical layers emerge from the cortical plate [4,5], leading to severe cortical lamination defects, adult mortality and seizures [5,6].
Negative_regulation (loss) of Cdk5 in neurons associated with convulsion
2) Confidence 0.29 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.49 Pain Relevance 0.16
In mice lacking Cdk5 or p35, abnormal formation of cortical layers occurs: a loss of the Cdk5 pathway appears to affect later migrating neurons as the cortical layers emerge from the cortical plate [4,5], leading to severe cortical lamination defects, adult mortality and seizures [5,6].
Negative_regulation (lacking) of Cdk5 in neurons associated with convulsion
3) Confidence 0.29 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.44 Pain Relevance 0.13
Following treatment with roscovitine, a specific inhibitor of cdk5, the release of eosinophil peroxidase (EPO) was measured in cells activated with secretory IgA-coated beads.
Negative_regulation (inhibitor) of cdk5 in eosinophil
4) Confidence 0.18 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.34 Pain Relevance 0.04

General Comments

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