INT221974

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Context Info
Confidence 0.56
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.99
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

embryo development (CDK5) cytoplasm (CDK5) cell proliferation (CDK5)
cytosol (CDK5) nucleocytoplasmic transport (CDK5) cell death (CDK5)
Anatomy Link Frequency
neurons 1
CDK5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 22 96.68 Very High Very High Very High
cerebral cortex 2 63.92 Quite High
Neuritis 2 32.24 Quite Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 4 99.28 Very High Very High Very High
Neurodegenerative Disease 22 97.32 Very High Very High Very High
Nervous System Malformation 18 97.16 Very High Very High Very High
Cognitive Disorder 8 84.12 Quite High
Congenital Anomalies 2 67.28 Quite High
Intellectual Impairment 10 56.00 Quite High
Convulsion 2 53.04 Quite High
Syndrome 6 50.88 Quite High
Neuritis 2 32.24 Quite Low
Disease 8 27.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The active CDK5-p35 complex is strongly involved in neurofilament phosphorylation and its aberrant hyperactivity has been shown to be implicated in neurodegenerative diseases [58].
Phosphorylation (phosphorylation) of CDK5 associated with neurodegenerative disease and attention deficit hyperactivity disorder
1) Confidence 0.56 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.59 Pain Relevance 0.11
During neuronal migration, p35-activated CDK5 phosphorylates NudEL, the homologous of an Aspergillus nidulans gene involved in nuclear translocation and in cytoskeletal organization of migrating neurons by dynein regulation [2].
Phosphorylation (phosphorylates) of CDK5 in neurons
2) Confidence 0.43 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.39 Pain Relevance 0.09

General Comments

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