INT221978

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 13
Disease Relevance 5.08
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (CDK5R1) cytosol (CDK5R1) plasma membrane (CDK5R1)
nucleus (CDK5R1) embryo development (CDK5R1) kinase activity (CDK5R1)
Anatomy Link Frequency
neurons 8
neuronal 4
CDK5R1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 143 96.72 Very High Very High Very High
cerebral cortex 13 89.72 High High
Neurotransmitter 13 72.64 Quite High
Neuritis 13 8.64 Low Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 143 97.80 Very High Very High Very High
Nervous System Malformation 117 96.08 Very High Very High Very High
Disease 52 96.08 Very High Very High Very High
Syndrome 39 95.96 Very High Very High Very High
Intellectual Impairment 65 95.84 Very High Very High Very High
Cognitive Disorder 52 95.04 Very High Very High Very High
Neurological Disease 13 94.80 High High
Attention Deficit Hyperactivity Disorder 26 91.32 High High
Congenital Anomalies 13 89.60 High High
Neuroblastoma 117 85.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results on interaction of the nELAV factors with CDK5R1 messenger in a neuronal cell line support the hypothesis of a neuron-specific post-transcriptional regulation of CDK5R1 expression.
Regulation (regulation) of Gene_expression (expression) of CDK5R1 in neuron
1) Confidence 0.59 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.15 Pain Relevance 0.05
According to our results we hypothize that an up- or down-regulation of CDK5R1 expression, caused by defective post-transcriptional mechanisms, may have pathogenetic implications in neurodegenerative disorders or cognitive impairment-based diseases, respectively.
Regulation (regulation) of Gene_expression (expression) of CDK5R1 associated with cognitive disorder, disease and neurodegenerative disease
2) Confidence 0.59 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.86 Pain Relevance 0.12
These data indicate that this motif does not seem to be involved in the regulation of CDK5R1 expression.
Regulation (regulation) of Gene_expression (expression) of CDK5R1
3) Confidence 0.59 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.08 Pain Relevance 0.04
Thus an up-regulation of CDK5R1 expression in neurons may have pathological implications causing neurodegenerative diseases.
Regulation (regulation) of Gene_expression (expression) of CDK5R1 in neurons associated with neurodegenerative disease
4) Confidence 0.59 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.72 Pain Relevance 0.09
Our findings evince the presence of both destabilizing and stabilizing regulatory elements in CDK5R1 3'-UTR and support the hypothesis that CDK5R1 gene expression is post-transcriptionally controlled in neurons by ELAV-mediated mechanisms.
Regulation (controlled) of Gene_expression (expression) of CDK5R1 in neurons
5) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC2222623 Disease Relevance 0.14 Pain Relevance 0
The CDK5R1 expression is likely to be finely controlled also in non-neuronal tissues.
Spec (likely) Regulation (controlled) of Gene_expression (expression) of CDK5R1 in neuronal
6) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.75 Pain Relevance 0.08
Our findings on non-neuronal cell lines suggest that the 3'-UTR might be involved in the post-transcriptional control of CDK5R1 expression in different tissues and that an alteration of this mechanism may cause cellular dysfunction and disease.
Regulation (control) of Gene_expression (expression) of CDK5R1 in neuronal associated with disease
7) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.65 Pain Relevance 0.07
The remarkable size of CDK5R1 3'-untranslated region (3'-UTR) suggests a role in post-transcriptional regulation of CDK5R1 expression.


Regulation (regulation) of Gene_expression (expression) of CDK5R1
8) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC2222623 Disease Relevance 0.28 Pain Relevance 0.05
These features suggest a role for the 3'-UTR in the control of CDK5R1 expression.
Regulation (control) of Gene_expression (expression) of CDK5R1
9) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.23 Pain Relevance 0.04
CDK5R1 3'-UTR is longer than the eukaryotic 3'-UTR average [24], belonging to the 5% longest annotated 3'UTRs [21] and was recently reported to contain potential post-transcriptional regulatory elements [19], suggesting that it may be important for the control of CDK5R1 gene expression.
Regulation (control) of Gene_expression (expression) of CDK5R1
10) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.09 Pain Relevance 0.04
Additional studies are necessary to validate the biological function of the predicted regulatory elements and to identify novel cis-acting regulatory motifs such as microRNA target sites, in order to evince the role of 3'-UTR in the regulation of CDK5R1 expression.
Regulation (regulation) of Gene_expression (expression) of CDK5R1
11) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.43 Pain Relevance 0
This is the first evidence of the involvement of 3'-UTR in the modulation of CDK5R1 expression.
Regulation (modulation) of Gene_expression (expression) of CDK5R1
12) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Abstract Doc Link PMC2222623 Disease Relevance 0.08 Pain Relevance 0
Our study evidences for the first time the involvement of 3'-UTR in the modulation of CDK5R1 expression by the presence of both destabilizing and stabilizing cis-regulatory elements in 3'-UTR, also supporting the hypothesis that CDK5R1 gene expression is controlled in neurons by nELAV-mediated mechanisms, with potential implications in neurodegenerative and cognitive disorders.
Regulation (modulation) of Gene_expression (expression) of CDK5R1 in neurons associated with cognitive disorder and neurodegenerative disease
13) Confidence 0.26 Published 2007 Journal BMC Mol Biol Section Body Doc Link PMC2222623 Disease Relevance 0.63 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox