INT2220

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Context Info
Confidence 0.61
First Reported 1979
Last Reported 2009
Negated 3
Speculated 2
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 2.16
Pain Relevance 3.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
hypothalamus 2
plasma 2
neurons 2
pituitary 2
brain 2
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 17 100.00 Very High Very High Very High
Morphine 9 100.00 Very High Very High Very High
Neurotransmitter 4 96.80 Very High Very High Very High
Central nervous system 8 95.64 Very High Very High Very High
Acupuncture 168 93.04 High High
noradrenaline 6 91.96 High High
opiate 5 88.88 High High
gABA 3 86.52 High High
agonist 4 85.56 High High
Serotonin 2 84.88 Quite High
Disease Link Frequency Relevance Heat
Galactorrhea 4 99.08 Very High Very High Very High
Pituitary Cancer 1 97.56 Very High Very High Very High
Urological Neuroanatomy 68 96.52 Very High Very High Very High
Precocious Puberty 86 91.60 High High
Polycystic Ovary Syndrome 186 85.12 High High
Stress 7 82.32 Quite High
Cancer 2 75.00 Quite High
Infection 1 75.00 Quite High
Anaemia 1 60.44 Quite High
Osteoporosis 1 59.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neural control of the synthesis and release of luteinizing hormone-releasing hormone.
Regulation (control) of Gene_expression (synthesis) of luteinizing hormone in Neural
1) Confidence 0.61 Published 1992 Journal Ciba Found. Symp. Section Title Doc Link 1425026 Disease Relevance 0.06 Pain Relevance 0.88
Effects of herb mixture on GnRH expression by immunohistochemistry
Regulation (Effects) of Gene_expression (expression) of GnRH
2) Confidence 0.61 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.09 Pain Relevance 0
From this point of view, we selected these regions to observe the change of GnRH expression.
Regulation (change) of Gene_expression (expression) of GnRH
3) Confidence 0.61 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.32 Pain Relevance 0.04
Pubertal changes in gonadotropin-releasing hormone and proopiomelanocortin gene expression in the brain of the male rat.
Regulation (changes) of Gene_expression (expression) of gonadotropin-releasing hormone in brain
4) Confidence 0.61 Published 1989 Journal Endocrinology Section Title Doc Link 2647464 Disease Relevance 0.06 Pain Relevance 0
This review summarizes the literature concerning the neuroendocrine mechanisms controlling GnRH biosynthesis and release in females of several induced ovulating species, and whenever possible it contrasts the results with those obtained for spontaneously ovulating species.
Regulation (controlling) of Gene_expression (biosynthesis) of GnRH
5) Confidence 0.60 Published 2000 Journal Front Neuroendocrinol Section Abstract Doc Link 10882541 Disease Relevance 0 Pain Relevance 0.06
In the present study, we sought to determine whether androgen exposure, starting before puberty, affects estrous cyclicity and hypothalamic expression of the AR, GnRH, GnRH-R, and CRH in adult female rats and whether the effects are mediated by the AR.
Spec (whether) Regulation (affects) of Gene_expression (expression) of GnRH
6) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.27 Pain Relevance 0.40
There was no consistent effect of any treatment on hypothalamic concentration of pro-LH releasing hormone (RH) (LHRH), LHRH, or on steady-state levels of LHRH mRNA.
Neg (no) Regulation (effect) of Gene_expression (levels) of LHRH mRNA
7) Confidence 0.45 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756033 Disease Relevance 0.12 Pain Relevance 0.20
These studies show that neither basal nor evoked LHRH output in vitro is affected by severe and chronic hyperprolactinemia produced by MtTW15 pituitary tumor cells in intact male rats.
Neg (neither) Regulation (affected) of Neg (neither) Gene_expression (output) of LHRH in pituitary associated with galactorrhea and pituitary cancer
8) Confidence 0.45 Published 1987 Journal Endocrinology Section Abstract Doc Link 3297642 Disease Relevance 0.35 Pain Relevance 0.38
The effect of LPS on Fos expression in GnRH neurones was also examined in association with its effect on steroid-induced LH release.
Regulation (effect) of Gene_expression (expression) of GnRH
9) Confidence 0.44 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716406 Disease Relevance 0.23 Pain Relevance 0.23
In the present study, we sought to determine whether androgen exposure, starting before puberty, affects estrous cyclicity and hypothalamic expression of the AR, GnRH, GnRH-R, and CRH in adult female rats and whether the effects are mediated by the AR.
Spec (whether) Regulation (affects) of Gene_expression (expression) of GnRH
10) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.28 Pain Relevance 0.40
[Effect on the administration of LHRH on LH and prolactin plasma levels in adult female rats ovariectomized and maintained in constant light (author's transl)].
Regulation ([Effect) of Gene_expression (administration) of LHRH in plasma
11) Confidence 0.38 Published 1979 Journal Rev. Esp. Fisiol. Section Title Doc Link 384483 Disease Relevance 0 Pain Relevance 0.07
Moreover, NE infusions did not alter single cell levels of LHRH mRNA in any region of the rostral hypothalamus.
Neg (not) Regulation (alter) of Gene_expression (levels) of LHRH mRNA in hypothalamus
12) Confidence 0.26 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8255183 Disease Relevance 0 Pain Relevance 0.47
The distribution of AR and GnRH overlapped, indicating a potential mechanism for the regulation of GnRH-expressing neurons by androgens.
Regulation (regulation) of Gene_expression (expressing) of GnRH in neurons
13) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 0.38 Pain Relevance 0
Effects of morphine and naloxone on serum levels of luteinizing hormone and prolactin in prepubertal male and female rats.
Regulation (Effects) of Gene_expression (levels) of luteinizing hormone associated with narcan and morphine
14) Confidence 0.09 Published 1979 Journal Neuroendocrinology Section Title Doc Link 514456 Disease Relevance 0 Pain Relevance 0.41

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