INT222014

Context Info Confidence 0.41 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.55 Pain Relevance 0.09

kinase activity (Map2k3)

Map2k3 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 36 85.64 cytokine 8 49.88 metalloproteinase 6 5.00 Mechanotransduction 4 5.00 ketamine 4 5.00 anesthesia 2 5.00 Inflammatory response 2 5.00 imagery 2 5.00

Disease Link Frequency Relevance Heat Lung Injury 116 99.34 INFLAMMATION 36 85.64 Sprains And Strains 8 76.48 Injury 16 67.40 Necrosis 6 50.48 Cancer 4 50.12 Death 14 19.60 Apoptosis 32 5.00 Pulmonary Edema 18 5.00 Adult Respiratory Distress Syndrome 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To further assess the role of p38 MAPK and JNK1 in VILI, we ventilated mice genetically deficient either in mkk3 (mkk3?

Negative_regulation (either) of Gene_expression (deficient) of mkk3 associated with lung injury

1) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.77 Pain Relevance 0.04

To further assess the role of p38 MAPK and JNK1 in VILI, we ventilated mice genetically deficient either in mkk3 (mkk3?

Negative_regulation (either) of Gene_expression (deficient) of mkk3 associated with lung injury

2) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2223071 Disease Relevance 0.77 Pain Relevance 0.04

General Comments

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