INT22202

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Context Info
Confidence 0.68
First Reported 1980
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 4.59
Pain Relevance 5.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ptgfr) plasma membrane (Ptgfr) signal transducer activity (Ptgfr)
Anatomy Link Frequency
PGE2 2
neurons 1
platelets 1
uterine 1
ear 1
Ptgfr (Mus musculus)
Pain Link Frequency Relevance Heat
bradykinin 4 100.00 Very High Very High Very High
Inflammatory mediators 7 99.22 Very High Very High Very High
lidocaine 10 98.14 Very High Very High Very High
Spinal cord 3 97.92 Very High Very High Very High
Dismenorea 5 97.28 Very High Very High Very High
aspirin 25 96.28 Very High Very High Very High
antagonist 106 96.16 Very High Very High Very High
tetrodotoxin 8 96.08 Very High Very High Very High
Inflammation 9 95.68 Very High Very High Very High
Pain 11 94.68 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 21 99.02 Very High Very High Very High
Disease 2 97.48 Very High Very High Very High
Dysmenorrhea 1 97.28 Very High Very High Very High
Arthritis 1 97.16 Very High Very High Very High
Pain 9 94.68 High High
Tinnitus 2 92.72 High High
Dizziness 2 91.92 High High
Neuropathic Pain 7 91.16 High High
Gastritis 2 90.80 High High
Natriuresis 6 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunostaining of beta-galactosidase, a reporter knocked into the endogenous FP locus in FP(-/-) mice, showed that the FP receptor was co-localized with P2X(2) and P2X(3) receptors in neurons of the spinal cord. alphabeta-Methylene ATP evoked a transient or sustained [Ca(2+)](i) increase in most of the PGF(2 alpha)-responsive cells in the deeper layer of the spinal cord, and the alphabeta-methylene ATP-evoked increase was blocked by the FP receptor antagonist AL-8810 in two-thirds of the cells.
Localization (localized) of FP receptor in neurons associated with antagonist and spinal cord
1) Confidence 0.68 Published 2009 Journal Neuroscience Section Abstract Doc Link 19490931 Disease Relevance 0.58 Pain Relevance 1.11
On the other hand, PGF2 alpha increases the synthesis of PGE2 and 6-keto PGF1 alpha while 6-keto PGF1 alpha solely inhibits PGF2 alpha release, PGE2 being inactive.
Localization (release) of PGF2
2) Confidence 0.63 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2608699 Disease Relevance 0.31 Pain Relevance 0.33
It appears that the release of PGE and PGF is dependent on uterine stretching and/or the subsequently induced uterine contractions.
Localization (release) of PGF in uterine associated with dismenorea
3) Confidence 0.38 Published 1983 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 6873748 Disease Relevance 0.10 Pain Relevance 0.10
The PGF-M decrease during the naproxen sodium treatment was significantly more prominent than that during both aspirin and placebo treatments (p = 0.0001).
Localization (decrease) of PGF-M associated with aspirin
4) Confidence 0.16 Published 1981 Journal Am. J. Obstet. Gynecol. Section Abstract Doc Link 7246695 Disease Relevance 0.29 Pain Relevance 0.84
Although the PGE2-induced mobilization of InsP via the FP receptor was less than that observed for PGF2?
Localization (mobilization) of FP receptor
5) Confidence 0.06 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.42 Pain Relevance 0.07
Moreover, we believe that these data have implications for the use of prostaglandin synthase inhibitors targeted against PGF synthase as therapeutic intervention strategies as suggested for PGE synthase (Murakami and Kudo, 2006; Jachak, 2007; Wang et al., 2006; Cheng et al., 2006).
Localization (targeted) of PGF synthase
6) Confidence 0.06 Published 2008 Journal Molecular and Cellular Endocrinology Section Body Doc Link PMC2694994 Disease Relevance 0.17 Pain Relevance 0.03
However, neither drug significantly changed the urinary excretion of PGF2 alpha, indicating that renal PG synthesis is not influenced by mineralocorticoids in the rabbit.
Localization (excretion) of PGF2
7) Confidence 0.03 Published 1980 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 7361561 Disease Relevance 0.21 Pain Relevance 0.24
The mean urinary PGE2 and PGF2 excretion was reduced by 35-63% and 63-85%, respectively.
Localization (excretion) of PGF2 in PGE2
8) Confidence 0.03 Published 1980 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 7361561 Disease Relevance 0.24 Pain Relevance 0.28
Urinary prostaglandin E2 (PGE2) and PGF2 excretion was previously found to be inversely related to sodium intake in the rabbit.
Localization (excretion) of PGF2 in PGE2
9) Confidence 0.03 Published 1980 Journal Acta Pharmacol Toxicol (Copenh) Section Abstract Doc Link 7361561 Disease Relevance 0.15 Pain Relevance 0.14
The addition of 10 microM lidocaine to the DNP treatment resulted in a significant attenuation in the rate of endogenous 6-keto PGF1 alpha release to values not different from those of the sham plus vehicle-treated group.
Localization (release) of PGF1 associated with lidocaine
10) Confidence 0.02 Published 1983 Journal Adv Shock Res Section Abstract Doc Link 6349294 Disease Relevance 0.23 Pain Relevance 0.80
Because NEP effectively cleaves tachykinins, we hypothesized that the inhibition of NEP would enhance a PGF2 alpha-induced bronchial contraction if PGF2 alpha stimulates the release of tachykinins.
Localization (release) of PGF2
11) Confidence 0.01 Published 1995 Journal J. Appl. Physiol. Section Abstract Doc Link 8593995 Disease Relevance 0 Pain Relevance 0.17
Thus the suppression of PGF2 alpha release does not reflect the therapeutic response of these drugs.
Localization (release) of PGF2
12) Confidence 0.01 Published 1981 Journal Scand. J. Rheumatol. Section Abstract Doc Link 7017917 Disease Relevance 0.54 Pain Relevance 0.22
Both ASA doses induced complete inhibition of prostaglandin PGF2 alpha release from platelets.
Localization (release) of PGF2 in platelets
13) Confidence 0.01 Published 1981 Journal Scand. J. Rheumatol. Section Abstract Doc Link 7017917 Disease Relevance 0.52 Pain Relevance 0.22
EFS of tracheal spirals also caused large increases in the release of certain prostanoids with release of prostaglandin (PG)D2, PGE2 and PGF2 alpha (16.5-, 3.0- and 4.1-fold, respectively).
Localization (release) of PGF2
14) Confidence 0.01 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7932167 Disease Relevance 0.07 Pain Relevance 0.31
The dose-response (dose, 0.01, 0.05, 0.1, 0.5, 1, and 5 mg) profiles of 10 atopic and 10 nonatopic subjects were determined for nasal patency, secretion weight, pulmonary function, eustachian tube function, middle-ear function, and symptoms after intranasal inhalation challenges with histamine, bradykinin, methacholine, prostaglandin D2, and prostaglandin F2 alpha (PGF2 alpha).
Spec (determined) Localization (secretion) of PGF2 in ear associated with bradykinin
15) Confidence 0.01 Published 1990 Journal J. Allergy Clin. Immunol. Section Abstract Doc Link 2262647 Disease Relevance 0.07 Pain Relevance 0.13
Indomethacin decreased the urinary excretion of PGF2 alpha by about 70% and 6-keto-PGF1 alpha and thromboxane (Tx)B2, the stable break-down products of prostacyclin and TxA2 respectively, by about 40%.
Localization (excretion) of PGF2
16) Confidence 0.00 Published 1989 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 2616586 Disease Relevance 0.27 Pain Relevance 0.05
We therefore investigated the effects of the inflammatory mediators, prostaglandin (PGD2, PGE2, PGI2, and PGF2 alpha) and leukotriene (LTC4), on guinea-pig colonic secretion and on electrophysiological behaviour of submucosal neurones.
Localization (secretion) of PGF2 associated with inflammatory mediators
17) Confidence 0.00 Published 1997 Journal Comp. Biochem. Physiol. A Physiol. Section Abstract Doc Link 9366066 Disease Relevance 0.42 Pain Relevance 0.43

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