INT222029

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.88
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Msc)
Anatomy Link Frequency
spinal cord 1
MSCs 1
Msc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
diabetic neuropathy 26 100.00 Very High Very High Very High
Spinal cord 177 98.80 Very High Very High Very High
hypoalgesia 5 86.88 High High
Inflammation 19 80.56 Quite High
Sciatic nerve 2 71.32 Quite High
chemokine 1 47.16 Quite Low
cytokine 7 44.68 Quite Low
Nerve growth factor 17 5.00 Very Low Very Low Very Low
neurotrophin 3 14 5.00 Very Low Very Low Very Low
isoflurane 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetic Neuropathy 27 100.00 Very High Very High Very High
Myocardial Infarction 6 98.26 Very High Very High Very High
Necrosis 3 98.12 Very High Very High Very High
Malignant Neoplastic Disease 9 96.88 Very High Very High Very High
Diabetes Mellitus 71 96.36 Very High Very High Very High
Cancer 42 95.52 Very High Very High Very High
Injury 17 91.68 High High
Adhesions 1 88.92 High High
Hypoalagesia 5 86.88 High High
Hypoxia 1 86.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS—These results suggest that MSC transplantation could have therapeutic effects on DPN through paracrine actions of growth factors secreted by MSCs.



Localization (secreted) of MSC in MSCs associated with diabetic neuropathy
1) Confidence 0.39 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2570407 Disease Relevance 0.69 Pain Relevance 0.22
Despite some tumorigenic characteristics of our hMSC cell transplants (high degree of Ki67-positivity, multiple mitoses, central necrosis, neovascularisation,...
Localization (degree) of hMSC associated with necrosis
2) Confidence 0.27 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.53 Pain Relevance 0.15
Immunological survival of hMSC-EGFP cell transplants in rat spinal cord
Localization (survival) of hMSC in spinal cord associated with spinal cord
3) Confidence 0.27 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.16 Pain Relevance 0.05
Stable genetic modification of hMSC
Localization (modification) of hMSC
4) Confidence 0.27 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0 Pain Relevance 0
For instance, the increase in MMP-9 level following the use of mobilizing agents such as SDF-1, VEGF and G-CSF or after a myocardial infarction, leads to an up-regulation of soluble kit, which ultimately results in an increase in MSC mobilization and proliferation [30, 31].
Localization (mobilization) of MSC associated with myocardial infarction
5) Confidence 0.17 Published 2007 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570564 Disease Relevance 0.51 Pain Relevance 0

General Comments

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