INT222031

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Context Info
Confidence 0.75
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 3.10
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Nt5e) cytoplasm (Nt5e)
Anatomy Link Frequency
neurons 1
epithelial cells 1
fibroblast 1
neutrophil 1
respiratory 1
Nt5e (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 7 95.60 Very High Very High Very High
Inflammation 166 94.24 High High
Spinal cord 122 92.52 High High
chemokine 64 91.56 High High
Pain 9 90.24 High High
adenocard 120 83.72 Quite High
Thermal hyperalgesia 8 75.76 Quite High
IPN 16 72.48 Quite High
Neuropathic pain 12 70.72 Quite High
Lasting pain 9 70.36 Quite High
Disease Link Frequency Relevance Heat
Nociception 20 98.24 Very High Very High Very High
Infection 147 97.28 Very High Very High Very High
INFLAMMATION 210 94.24 High High
Hypersensitivity 3 94.08 High High
Obesity 1 90.72 High High
Pain 18 90.24 High High
Lower Respiratory Tract Infection 7 86.44 High High
Hypoxia 38 84.48 Quite High
Respiratory Syncytial Virus 99 81.68 Quite High
Toxicity 8 81.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, we observed that NT5E was extensively co-localized with Prostatic acid phosphatase (PAP, also known as ACPP, Fluoride-resistant acid phosphatase or thiamine monophosphatase) in nociceptive neurons.
Localization (localized) of NT5E in neurons associated with nociception
1) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 1.16 Pain Relevance 0.75
EGFP-negative cells present in the cultures displayed a clearly different morphology (data not shown) and presumably were rat fibroblast cells as they were not recognized by antibodies directed against human CD29 and CD73 (Figure 7, hCD29 vs. hCD73 dot plot on EGFP-negative cells).
Localization (directed) of CD73 in fibroblast
2) Confidence 0.73 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.14 Pain Relevance 0.09
Further analysis revealed that the EGFP positive cells were indeed hMSC-NT3-EGFP cells as they stained positive for antibodies directed against human CD29 and CD73, both markers present on parental hMSC-NT3-EGFP cells (Figure 7, hCD29 vs. hCD73 dot plot on EGFP-positive cells).
Localization (directed) of CD73
3) Confidence 0.73 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.09 Pain Relevance 0.06
Monoclonal antibodies conjugated with fluorescein isothiocyanate (FITC) or phycoerythrin (PE) were used for the analysis and all antibodies were purchased from BD Pharmingen except for CD34 and CD73 which were obtained from eBioscience.
Neg (except) Localization (purchased) of CD73
4) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2270908 Disease Relevance 0.14 Pain Relevance 0
The activity of secreted mNT5E was initially determined in vitro.
Localization (secreted) of mNT5E
5) Confidence 0.65 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0
In an effort to produce a secreted and soluble (non-membrane anchored) version of NT5E, Servos and colleagues generated a baculovirus expression construct of rat NT5E that reportedly lacked the GPI-anchor at Ser523 [34].
Localization (secreted) of NT5E
6) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.16 Pain Relevance 0.05
The supernatant containing secreted GST-mNT5E was filtered (0.45 ?
Localization (secreted) of mNT5E
7) Confidence 0.57 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0
for CD73, sense primer 5?
Localization (sense) of CD73
8) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2556398 Disease Relevance 0.33 Pain Relevance 0.13
To acquire iron within the host, bacteria secrete siderophores such as enterobactin (Ent) that bind ferric iron with greater affinity than mammalian proteins.
Localization (secrete) of Ent
9) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0 Pain Relevance 0
The data from this study suggest the following model in which Lcn2 monitors iron utilization by bacteria and activates the immune response when iron stores become depleted: At low bacterial density, secreted Ent binds Fe and Lcn2 in turn binds Fe-Ent to prevent delivery of iron to bacteria.
Localization (secreted) of Ent
10) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.22 Pain Relevance 0.19
The cells were incubated overnight sequentially at 4°C with primary antibodies raised against CD105 1:200, mouse (BD Biosciences, San Jose, CA, USA), CD73 1:200, mouse (Santa Cruz Biotecnology, Inc., Santa Cruz, CA, USA), CD90 1:200, mouse (Santa Cruz Biotecnology, Inc., Santa Cruz, CA, USA), and CD34 1:200, mouse (Santa Cruz Biotecnology, Inc., Santa Cruz, CA, USA).
Localization (raised) of CD73
11) Confidence 0.12 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0 Pain Relevance 0
In addition, Lcn2 bound to Ent stimulates release of the neutrophil-recruitment signal IL-8 from cultured respiratory cells.
Localization (release) of Ent in respiratory
12) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.10
The induction of the neutrophil chemoattractant IL-8 in vitro suggests that Ent release by colonizing bacteria may stimulate neutrophil recruitment during infection.
Localization (release) of Ent in neutrophil associated with infection
13) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.16 Pain Relevance 0.06
Culture supernatant from the wild type was partially sensitive to Lcn2, indicating that K. pneumoniae secretes a mixture of Lcn2-sensitive and resistant Ent (Figure 5C).


Localization (secretes) of Ent
14) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.07 Pain Relevance 0
The Fe-Ent-Lcn2 complex is internalized by respiratory epithelial cells [8], and could serve as both a signal of controlled colonization and a mechanism of iron recycling.
Localization (recycling) of Ent in epithelial cells
15) Confidence 0.10 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.23 Pain Relevance 0.22
Whereas co-incubation of Ent with Lcn2 induced IL-8 release greater than 20-fold, co-incubation of Gly-Ent and Lcn2 did not stimulate IL-8 release above the level induced by Lcn2 alone (Figure 8).
Localization (release) of Ent
16) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2757716 Disease Relevance 0.20 Pain Relevance 0.09

General Comments

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