INT222076

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.22
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lysosome (Sgsh)
Sgsh (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 7 97.60 Very High Very High Very High
fibrosis 2 32.48 Quite Low
Calcium channel 7 5.00 Very Low Very Low Very Low
TRP channel 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Glutamate receptor 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
qutenza 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mucopolysaccharidoses 11 97.36 Very High Very High Very High
Lysosome Storage Disease 6 89.36 High High
Neuropathic Pain 9 84.40 Quite High
Lysosomal Storage Diseases 24 83.44 Quite High
Gauchers Disease 11 67.68 Quite High
Disease 9 60.24 Quite High
Cystic Fibrosis 2 33.04 Quite Low
Hypertension 2 5.00 Very Low Very Low Very Low
Anaemia 1 5.00 Very Low Very Low Very Low
Pompes Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prevalent S66W or R245H heparan sulfate sulfamidase (SGSH) mutations in type IIIA MPS reduce mutant enzyme concentrations in the lysosome, most likely due to impaired folding and ERAD in lieu of efficient folding and trafficking of sulfamidase, leading to the accumulation of heparan sulfate and severe CNS degeneration [27].
Gene_expression (trafficking) of sulfamidase associated with mucopolysaccharidoses and central nervous system
1) Confidence 0.04 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 1.22 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox