INT222077

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Context Info
Confidence 0.37
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.78
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hsp90b1) protein folding (Hsp90b1) cytosol (Hsp90b1)
endoplasmic reticulum (Hsp90b1) RNA binding (Hsp90b1) response to stress (Hsp90b1)
Anatomy Link Frequency
neurons 1
muscle fibers 1
Neuro-2a 1
Hsp90b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory stimuli 3 97.08 Very High Very High Very High
depression 18 93.20 High High
Inflammation 35 87.72 High High
cytokine 2 82.84 Quite High
Calcium channel 7 72.24 Quite High
anticonvulsant 6 11.56 Low Low
gABA 24 9.04 Low Low
Central nervous system 7 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
Migraine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 212 99.74 Very High Very High Very High
Manic Depressive Disorder 114 98.80 Very High Very High Very High
INFLAMMATION 29 97.08 Very High Very High Very High
Depression 18 93.20 High High
Oxidative Phosphorylation Disease 18 87.04 High High
Psychosis 6 84.04 Quite High
Myositis 42 80.84 Quite High
Deafness 6 78.80 Quite High
Optic Atrophy 6 78.28 Quite High
Diabetes Mellitus 6 77.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 3B shows that lithium treatment of Neuro-2a cells did not change the ratio between immunoprecipitated WFS1 and GRP94.
Neg (not) Regulation (change) of GRP94 in Neuro-2a
1) Confidence 0.37 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
Interestingly, a single LPS injection increased significantly Grp75 protein levels in skeletal muscle fibers, in the absence of both Grp94 [24] and MHC-I upregulation (present manuscript), proving that systemic inflammatory stimuli do raise the expression of this antioxidant stress-protein in muscle fibers.
Regulation (absence) of Grp94 in muscle fibers associated with stress and inflammatory stimuli
2) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888201 Disease Relevance 0.94 Pain Relevance 0.25
Here we show that valproate regulates WFS1 and GRP94 in neurons.
Regulation (regulates) of GRP94 in neurons
3) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.46 Pain Relevance 0.09
Mood stabilizers modulate WFS1-GRP94 complex
Regulation (modulate) of GRP94
4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0 Pain Relevance 0
We propose that the therapeutic effect of valproate is partially mediated by modulation of ER stress through the regulation of WFS1 and GRP94.
Regulation (regulation) of GRP94 associated with stress
5) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.36 Pain Relevance 0
It would be possible that geldanamycin as well as its less toxic analogues, 17-AAG and GA, may synergize with valproate and increase its effect on WFS1 expression and modulation of the WFS1-GRP94 complex.
Regulation (modulation) of GRP94
6) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 0.44 Pain Relevance 0
Our data raise the possibility that the therapeutic effects of valproate in bipolar disorder may be mediated by the modulation of ER stress through the regulation of WFS1 and GRP94.


Regulation (regulation) of GRP94 associated with stress and manic depressive disorder
7) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2607540 Disease Relevance 1.22 Pain Relevance 0.07
That the expression levels of GRP94, Hsp70, calnexin, and calreticulin were not changed significantly was also confirmed at the protein level.
Neg (not) Regulation (changed) of GRP94
8) Confidence 0.14 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2225441 Disease Relevance 0.05 Pain Relevance 0.04
Time-course data for the changes in the protein levels of glucose-regulated protein (GRP)78/BiP, the phosphorylated form of eukaryotic initiation factor 2?
Regulation (changes) of glucose-regulated protein
9) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 0.31 Pain Relevance 0

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